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Phylogenetic tree analysis based on sequence alignment of catalytic domains of subtilases from various organisms. PfSUB2 and PfSUB1 appear to diverge from known eukaryotic subtilases and to be more similar to the bacterial enzymes. DdTAGB and human S1P/SKI-1 are the most related eukaryotic subtilases and with PfSUB2 and PfSUB1 define a subclass of eukaryotic subtilases.
