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. 2005 Dec;83(4):801–823. doi: 10.1111/j.1468-0009.2005.00401.x

Figure 7.

Figure 7

An Incremental Model of Chronic Disease. The model is characterized by early age of onset, progression at various rates, and passage of a symptomatic threshold at which time a clinical diagnosis may be made. Reprinted with permission from J.F. Fries and L.M. Crapo, Vitality and Aging (San Francisco: W.H. Freeman, 1981).