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. 2008 Dec;86(4):557–580. doi: 10.1111/j.1468-0009.2008.00534.x

TABLE 2.

Number of Outcomes Prevented with Population-Based and Targeted Prevention Strategies

Outcomes Prevented over 5 Years among Adults 30+Years of Age with No History of CV Disease
% Adult Population Treated Total in U.S. Population (in Millions) Rate per 1,000 Persons Treated NNTa
Treatment Scenario Events Mortality Events Mortality Events Mortality
Population-based strategy Low intensity 100 0.75 0.14 6.4 1.2 156 850
Moderate intensity 100 1.87 0.34 16.0 2.9 62 340
LDL-targeted strategy 25 0.79 0.15 27.1 5.2 37 193
Risk-targeted strategy 25 1.56 0.40 53.8 13.7 19 73
a

NNT = Number needed to treat to prevent one CV event or CV death.