TABLE 3.

Consequence of Treatment's Adverse Effects on QALYs in Population-Based and Targeted Prevention Strategies

			Net QALYsa Gained over 5 Years among Adults 30+ Years of Age with No History of CV Disease
			Total in U.S. Population (in Millions)		Rate per 1,000 Persons Treated		NNTb
Treatment Scenario		% Adult Population Treated	Very Small Adverse Effect	Small Adverse Effect	Very Small Adverse Effect	Small Adverse Effect	Very Small Adverse Effect	Small Adverse Effect
Population-based strategy	Low intensityc	100	0.72	0.72	6.2	6.2	161	161
		Moderate intensity	100	1.23	0.65	10.6	5.6	95	179
LDL-targeted strategy		25	0.58	0.38	19.8	13.0	51	77
Risk-targeted strategy		25	1.53	1.33	52.4	45.5	19	22

^aQALYs = Quality-adjusted life years.

^bNNT = Number needed to treat to gain one QALY.

^cThe low-intensity population-based strategy was assumed to have no associated adverse effects.