Table I.

Proteins significantly down- or up-regulated

Gel IDs are numbers from Fig. 1, and accession numbers are from Swiss-Prot. Abbreviated gene names are as indicated from the Ingenuity Pathways Knowledge Base (14). -Fold change refers to ratios as identified by DeCyder software. Further data on identifications and statistics are presented in supplemental Table 2.

Gel ID	Abbreviation/gene	Protein accession no.	Name of protein	-Fold change
Down-regulated proteins
1	MBP	P04370	Myelin basic protein	−3.10
2	ETFA	Q3THD7	Electron transfer flavoprotein subunit α	−2.12
3	MTAP	Q9CQ65	S-Methyl-5-thioadenosine phosphorylase	−2.03
4	DSTN	Q9R0P5	Destrin (actin-depolymerizing factor)	−1.97
5	INSL3	Q5RL10	Insulin-like 3	−1.92
6	ABAT	P61922	4-Aminobutyrate aminotransferase	−1.76
7	FABP5	Q05816	Fatty acid-binding protein, epidermal	−1.65
8	ALDH5A1	Q8BWF0	Succinate-semialdehyde dehydrogenase	−1.56
9	VDAC1	Q60932	Voltage-dependent anion-selective channel protein 1	−1.50
10	FIS1	Q9CQ92	Mitochondrial fission 1 protein	−1.50
11	ESD	Q9R0P3	S-Formylglutathione hydrolase	−1.48
12	ARPC4	P59999	Actin-related protein 2/3 complex subunit 4	−1.48
13	HINT3	Q9CPS6	Histidine triad protein 4	−1.47
14	FABP5	Q05816	Fatty acid-binding protein, epidermal	−1.46
15	DPYSL2	O08553	Dihydropyrimidinase-related protein 2	−1.44
16	HAGH	Q99KB8	Hydroxyacylglutathione hydrolase	−1.42
17	DBI	P31786	Acyl-CoA-binding protein	−1.39
18	CNP	P16330	2′,3′-Cyclic-nucleotide 3′-phosphodiesterase	−1.39
19	CPLX1	P63040	Complexin	−1.38
20	TST	P52196	Thiosulfate sulfurtransferase	−1.32
21	NUDT2	P56380	Nucleoside diphosphate-linked moiety X type motif 2	−1.31
22	ANXA5	P48036	Annexin A5	−1.30
23	RPS27A	P62991	Ubiquitin	−1.30
24	APOA1BP	Q8K4Z3	ApoA-I-binding protein	−1.29
25	GRB2	Q60631	Growth factor receptor-bound protein 2	−1.25
Up-regulated proteins
26	IDE	Q9JHR7	Insulin-degrading enzyme	1.31
27	DNM1	Q05193	Dynamin	1.31
28	PGAM1	Q9DBJ1	Phosphoglycerate mutase	1.32
29	ACTG1	Q3TSB7	Actin-γ	1.34
30	SUCLA2	Q9Z2I9	Succinyl-CoA ligase	1.34
31	STIP1	Q60864	STI (stress-induced) phosphoprotein 1	1.35
32	CYC1	Q9D0M3	Cytochrome c1, heme protein, mitochondrial precursor	1.35
33	SOD2	P09671	Mn-SOD	1.36
34	C3ORF10	Q91VR8	Brick 1	1.37
35	CAPNS1	O88456	Calpain smaller subunit	1.40
36	MLF2	Q99KX1	Myeloid leukemia factor 2	1.40
37	AKR1A1	Q9JII6	Alcohol dehydrogenase (NADP+)	1.42
38	MDH1	P14152	Malate dehydrogenase	1.43
39	COPS4	O88544	COP9 (signalosome complex) subunit 4	1.43
40	CKB	Q04447	Creatine kinase B-type	1.44
41	YWHAG	P61982	14-3-3 protein γ	1.44
42	BLVRA	Q9CY64	Biliverdin reductase A precursor	1.47
43	COPS8	Q8VBV7	COP9 (signalosome complex) subunit 8	1.47
44	TPRG1L	Q9DBS2	Tumor protein p63-regulated gene 1-like protein	1.49
45	MDH1	P14152	Malate dehydrogenase	1.52
46	IDH1	O88844	Isocitrate dehydrogenase (NADP) cytoplasmic	1.52
47	ERP29	P57759	Endoplasmic reticulum protein 29	1.53
48	ACTG1	Q3TSB7	Actin-γ	1.53
49	ACTG1	Q3TSB7	Actin-γ	1.56
50	CKB	Q04447	Creatine kinase B-type	1.62
51	COPS8	Q8VBV7	COP9 (signalosome complex) subunit 8	1.71
52	UCHL1	Q9R0P9	Ubiquitin carboxyl-terminal hydrolase isozyme L1	1.75
53	UBE2L3	P68037	Ubiquitin-conjugating enzyme E2 L3	1.81