Table III.
Canonical pathways
Proteins identified were uploaded to the Ingenuity Pathways Knowledge Base and subjected to canonical pathway analysis. This identifies canonical pathways that are overrepresented among the identified proteins in a way that is not likely to be by chance. Abbreviations are as in Table I. Up-regulated proteins are shown in bold. GABA, γ-aminobutyric acid.
| Canonical pathways | p value | Proteins |
|---|---|---|
| Pyruvate metabolism | 0.0001 | HAGH, ALDH5A1, MDH1, AKR1A1 |
| Citrate cycle | 0.0002 | MDH1, SUCLA2, IDH1 |
| NRF-2-mediated oxidative stress response | 0.0004 | AKR1A1, SOD2, ERP29, STIP1, ACTG1 |
| GABA receptor signaling | 0.0006 | ABAT, ALDH5A1, DNM1 |
| β-Alanine metabolism | 0.0009 | ABAT, DPYSL2, ALDH5A1 |
| Propanoate metabolism | 0.001 | ABAT, ALDH5A1, SUCLA2 |
| Glycolysis/gluconeogenesis | 0.005 | ALDH5A1, AKR1A1, PGAM1 |
| Integrin signaling | 0.005 | GRB2, ARPC4, CAPNS1, ACTG1 |
| Actin cytoskeleton signaling | 0.006 | GRB2, ARPC4, C3ORF10, ACTG1 |
| Glutamate metabolism | 0.008 | ABAT, ALDH5A1 |