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. 2009 Jun;8(6):1278–1294. doi: 10.1074/mcp.M800493-MCP200

Table II.

Tamoxifen-response protein profile

Name, ratio, p value, IPI number, molecular mass, localization are given on the putative 100-protein profile. The order and numbering are identical to Fig. 4. EPH, ephrin; snRNA, small nucleolar RNA; GDNF, glial cell-derived neurotrophic factor.

No.a Protein description Ratio of geometric means, OR:PD Wilcoxon rank sum IPI Gene symbol Molecular mass Localizationb
kDa
1 EPH receptor B2 0.458 0.0057 IPI00252979.7 EPHB2 (ERK, EPTH3) 110 Membrane
2 Splice isoform 1 of protein kinase C and casein kinase substrate in neurons protein 2 0.538 0.0366 IPI00027009.2 PACSIN2 56 Cytoplasm
3 40 S ribosomal protein S4, X isoformc,d 0.478 0.0412 IPI00217030.5 RPS4X (SCAR) 29 Ribosome
4 Calponin-2c 0.478 0.0134 IPI00015262.9 CNN2 33.5 Cytoskeleton
5 Calgranulin Bc,d 0.483 0.0127 IPI00027462.1 S100A9 (CAGB, MRP14) 13 Cytoplasm
6 Anchor attachment protein 1 0.513 0.047 IPI00021594.2 GPAA1 68 ER
7 Epididymal secretory protein E1 precursor 0.54 0.0085 IPI00301579.3 NCP2 16.5 Secreted protein
8 Pyrroline-5-carboxylate reductase 1c,d 0.49 0.0274 IPI00550882.2 PYCR1 (P5CR1) 33 u
9 Nucleolar protein NOP5c 0.453 0.0202 IPI00006379.1 NOP5 (HSPC120) 60 Nucleus
10 Annexin A8 0.394 0.0127 IPI00218835.4 ANXA8 (ANX8) 37 u
11 Lysyl-tRNA synthetasec,d 0.539 0.0127 IPI00014238.2 KARS (KIAA0070) 68 Cytoplasm
12 Syntaxin 7 0.484 0.0338 IPI00289876.2 STX7 30 Endosome
13 Splice isoform 2 of basigin precursore 0.342 0.0004 IPI00019906.1 BSG (EMMPRIN, CD147) 42 Cell membrane
14 FLJ20625 protein 0.457 0.0411 IPI00016670.2 FLJ20625 18 u
15 Eukaryotic translation initiation factor 5 0.491 0.003 IPI00022648.2 EIF5 49 Cytosol
16 Splice isoform 1 of Surfeit locus protein 4c,d 0.449 0.0097 IPI00005737.1 SURF4 30 ER
17 Splice isoform 1 of calumenin precursorc,d 0.514 0.0222 IPI00014537.1 CALU 38 ER/Golgi
18 Coronin-1Ac,d 0.507 0.0179 IPI00010133.1 CORO1A (CLIPINA) 51 Actin cytoskeleton
19 RAS-related protein RAB-10c 0.516 0.0412 IPI00016513.3 RAB10 22.5 Cell membrane
20 Splice isoform long of potential phospholipid-transporting ATPase IIA 0.519 0.0221 IPI00024368.1 ATP9A (ATPIIA, KIAA0611) 119 Membrane
21 DNA replication licensing factor MCM2 0.528 0.0292 IPI00184330.5 MCM2 (BM28, CDCL1, KIAA0030) 102 Nucleus
22 Splice isoform long of splicing factor, proline- and glutamine-richc,d 0.475 0.0179 IPI00010740.1 SFPQ (PSF) 76 Nucleus
23 Collagen-binding protein 2 precursorc,d 0.534 0.0114 IPI00032140.2 SERPINH1 (SERPINH2, CBP2, HSP47, Colligin) 46 ER
24 Small nuclear ribonucleoprotein SM D2c,d 0.495 0.0412 IPI00017963.1 SNRPD2 (Sm-D2) 13.5 Nucleus
25 4F2 cell surface antigen heavy chainc,d 0.546 0.05 IPI00027493.1 SLC3A2 (MDU1) 58 Membrane
26 Growth factor receptor-bound protein 7 0.483 0.038 IPI00448767.3 GRB7 60 u
27 Copine I 0.507 0.0221 IPI00018452.1 CPNE1 (CPN1) 59 u
28 Serum amyloid A protein precursor 0.442 0.0055 IPI00022368.1 SAA1 (SAA2) 13.5 u
29 Ephrin type-A receptor 2 precursor 0.503 0.0221 IPI00021267.1 EPHA1 (ECK) 108 Membrane
30 T-complex protein 1, η subunitc,d 0.492 0.05 IPI00018465.1 CCT7 (TCP-1η, CCTH) 59 Cytoplasm
31 Guanine nucleotide-binding protein β subunit 4c,d 0.53 0.0403 IPI00012451.1 GNB4 37 u
32 Metalloprotease 1 0.494 0.022 IPI00219613.3 PITRM1 (hMP1) 117 Mitochondrion
33 C-1-Tetrahydrofolate synthase, cytoplasmicc 0.485 0.0275 IPI00218342.9 MTHFD1 (MTHFC) 101 Cytoplasm
34 Predicted: septin 8 0.54 0.0179 IPI00022082.4 SEPT8 (KIAA0202) 50 u
35 Acetolactate synthase homolog 0.465 0.0135 IPI00549240.1 OR10B1P (ILVBL) 68 u
36 Predicted: hypothetical protein XP_114317 0.511 0.0085 IPI00145623.1 RPL22L1 15–21 u
37 Prefoldin subunit 6 0.512 0.0395 IPI00005657.1 PFDN6 (HKE2) 14.5 Cytosol
38 NADH-cytochrome b5 reductasec,d 0.395 0.0071 IPI00328415.8 CYB5R3 (DIA1) 34 ER/mitochondrion/cytoplasm
39 Adenylate kinase isoenzyme 4, mitochondrial 0.428 0.0036 IPI00016568.1 AK3L1(AK3, AK4) 25 Mitochondrion
40 Phosphoprotein enriched in astrocytes 15c 0.481 0.0363 IPI00014850.3 PEA15 (PED) 15 Cytoplasm
41 Thioredoxin domain-containing protein 5 0.51 0.0496 IPI00171438.2 TXNDC5 (TLP46, ERp46) 48 ER
42 Coronin-1Bc,d 0.425 0.0055 IPI00007058.1 CORO1B 54 Leading edge
43 Ephrin type-B receptor 3 precursor 0.455 0.0077 IPI00289329.1 EPHB3 (ETK2, HEK2) 110 Membrane
44 RAB11 family-interacting protein 1Bc 0.518 0.0191 IPI00419433.1 RAB11 FIP1(RCP) 137 Membrane
45 Splice isoform 1 of exocyst complex component SEC6 0.467 0.0231 IPI00157734.2 EXOC3 (SEC6, SEC6L1) 87 u
46 Splice isoform 1 of protein C20ORF116 precursor 0.54 0.0266 IPI00028387.3 C20ORF116 36 Secreted protein
47 Hypothetical protein DKFZP434E248 0.525 0.0221 IPI00300094.5 LSG1 75 u
48 Adenylate kinase 2 isoform Ac,d 2.036 0.0338 IPI00215901.1 AK2 (ADK2) 26 Mitochondrion
49 Trifunctional enzyme α subunit, mitochondrial precursorc,d 2.105 0.0071 IPI00031522.2 HADHA (HADH) 83 Mitochondrion
50 Nucleosome assembly protein 1-like 1c,d 1.847 0.0275 IPI00023860.1 NAP1L1 (NRP) 45 Nucleus
51 Secretory carrier-associated membrane protein 1 2.301 0.0055 IPI00005129.6 SCAMP1 40 Membrane
52 Sphingosine-1-phosphate lyase 1d 1.924 0.0135 IPI00099463.2 SGPL1 64 ER membrane
53 Splice isoform 1 of glucosamine-fructose-6-phosphate aminotransferase (isomerizing) 1c,d 2.377 0.0101 IPI00217952.6 GFPT1 (GFAT) 79 u
54 Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial precursorc,d 1.991 0.0236 IPI00026964.1 UQCRFS1 30 Mitochondrion
55 U6 snRNA-associated SM-like protein LSM2 1.906 0.0394 IPI00032460.3 LSM2 (G7B) 10 Nucleus
56 Lisch protein, isoform 2 2.178 0.0084 IPI00409640.1 LSR (LISCH) 71 Membrane
57 Splice isoform 1 of epsin 4 2.385 0.0064 IPI00291930.5 CLINT1 (EPN4) 68 Cytoplasm
58 Endothelial protein C receptor precursor 1.932 0.0178 IPI00009276.1 PROCR (EPCR) 30 Membrane
59 Annexin VI isoform 2c,d 2.035 0.0114 IPI00002459.3 ANXA6 75 u
60 Pyridoxine-5′-phosphate oxidase 2.081 0.0238 IPI00018272.3 PNPO 30 u
61 Ectonucleotide pyrophosphatase/phosphodiesterase 1d 2.087 0.0193 IPI00184311.2 ENPP1 (NPPS, PC1) 105 Membrane
62 Protein C20ORF178, charged multivesicular body protein 4bc,d 1.997 0.0275 IPI00025974.3 CHMP4B (SHAX1) 25 Cytoplasm
63 Occludind 1.848 0.0178 IPI00003373.1 OCLN 59 Membrane
64 Adipose most abundant gene transcript 2c 2.099 0.0141 IPI00020017.1 APM2(C10ORF116) 8 u
65 Eukaryotic translation initiation factor 3 subunit 4 2.413 0.0062 IPI00290460.3 EIF3F 36 u
66 Hypothetical protein MGC5395c,d 1.896 0.05 IPI00031605.1 AHNAK 16 u
67 Splice isoform 2 of methylcrotonoyl-CoA Carboxylase β chain, mitochondrial precursor 1.902 0.0066 IPI00294140.4 MCCC2 (MCCB) 58 Mitochondrion
68 Tubulin β-3 chainc,d 1.907 0.009 IPI00013683.2 TUBB3 (TUBB4) 50 u
69 KIAA2014 protein (formin-like protein 1) 2.091 0.0236 IPI00385874.4 KIAA2014 117 u
70 Hypothetical protein FLJ90697 2.348 0.0377 IPI00329600.3 u
71 Hypothetical protein, isoform 1 of protein CDV3 homolog 1.986 0.0193 IPI00014197.1 CDV3 22–27 u
72 ATP synthase oligomycin sensitivity conferral protein, mitochondrial precursorc,d 2.153 0.0179 IPI00007611.1 ATP5O (ATPO) 23 Mitochondrion
73 Ubiquilin-2 1.843 0.0412 IPI00409659.1 UBQLN2 (PLIC2) 66 Cytoplasm/nucleus
74 Ubiquitin and ribosomal protein S27Ac,d 2.273 0.0071 IPI00179330.5 RP27A 18 Ribosome
75 Tubulin α-1 chainc,d 1.953 0.0222 IPI00007750.1 TUBA1 50 u
76 ATP synthase α chain, mitochondrial precursorc,d 1.947 0.0412 IPI00440493.2 ATP5O (ATPO) 60 Mitochondrion
77 Chaperonin containing TCP1, subunit 3c,d 1.872 0.0412 IPI00290770.2 CCT3 60 Cytoplasm
78 Nascent polypeptide-associated complex α subunitc,d 2.159 0.0143 IPI00023748.3 NACA (HSD48) 23 Cytoplasm/nucleus
79 Emerin 2.189 0.0178 IPI00032003.1 EMD 29 Nuclear inner membrane
80 Hypothetical protein KIAA0152c,d 1.974 0.0412 IPI00029046.1 KIAA0152 32 Membrane
81 Histone H1.5c,d 2.533 0.05 IPI00217468.2 HIST1H1B (H1F5) 23 Nucleus
82 Cation channel TRPM4B 2.03 0.0465 IPI00294933.6 TRPM4B (TRPM4) 134 Membrane
83 Calcyclinc,d 2.122 0.0363 IPI00027463.1 S100A6 (CACY) 10 Cytoplasm/nucleus
84 Splice isoform 2 of GDNF family receptor α 1 precursor 2.26 0.0184 IPI00220291.1 GFRA1 (GDNFRA, TRNR1) 51 Cell membrane
85 Complement component 1, Q subcomponent-binding protein, mitochondrial precursorc,d 2.222 0.0274 IPI00014230.1 C1QBP (GC1QBP) 31 Mitochondrion
86 Chloride intracellular channel protein 4c,d 2.023 0.0275 IPI00001960.2 CLIC4 29 Cytoplasm/mitochondrion
87 Eukaryotic translation initiation factor 3 subunit 6c,d 2.076 0.0178 IPI00013068.1 EIF3E (INT6) 52 Cytoplasm
88 Protein-disulfide isomerase A4 precursorc,d 2.157 0.0275 IPI00009904.1 PDIA4 (ERP70) 73 ER
89 Hypothetical protein MGC5352c,d 1.867 0.0394 IPI00063242.3 PGAM5 28 u
90 Splice isoform 1 of polypeptide N-acetylgalactosaminyltransferase 3d 2.229 0.0066 IPI00004670.1 GALNT3 73 Golgi
91 OTTHUMP00000028732 (thioredoxin, mitochondrial precursor) 1.823 0.0462 IPI00017799.3 TXN2 (TRX2) 18–22 Mitochondrion
92 Fatty acid-binding protein, epidermal 2.203 0.0075 IPI00007797.1 FABP5 15 Cytoplasm
93 Programmed cell death 6-interacting protein, PDCD6IP proteinc,d 2.202 0.0199 IPI00246058.3 PDCD6IP (AIP1) 97 Cytoplasm
94 Ezrin-radixin-moesin-binding phosphoprotein 50c,d 2.42 0.0025 IPI00003527.3 SLC9A3R1 (EBP50, NHERF1) 39 Intracytoplasmic membrane, actin cytoskeleton
95 Splice isoform 1 of ubiquitin thiolesterase protein 1.974 0.05 IPI00549574.2 OTUB1 u
96 Endozepinec,d 2.184 0.0211 IPI00010182.3 ACBP (DBI, EZ) 10 u
97 Phosphoribosylformylglycinamidine synthase 2.221 0.0177 IPI00004534.3 PFAS (KIAA0361) 145 Cytoplasm
98 Histidine triad nucleotide-binding protein 1c 1.853 0.0274 IPI00239077.4 HINT1 (PKCI1) 14 Cytoplasm/nucleus
99 BAG family molecular chaperone regulator-3 1.97 0.0175 IPI00000644.3 u
100 Exocyst complex component SEC8d 1.856 0.0109 IPI00059279.5 EXOC4 (KIAA1699, SEC8) 110 u
a

Numbering according to Fig. 4.

b

u, data unknown in database; ER, endoplasmic reticulum.

c

Presence verified in individual tumors by MS/MS.

d

Presence verified in individual tumor MS survey spectrum and quantified by AMT database match.

e

Validated by immunohistochemistry.