Table 4.

Secondary analyses: Multivariable-adjusted Regression of Individual Biomarkers on Ankle-brachial Index^*

	Geometric Means and 95% Confidence Intervals† Ankle-brachial index Level
Biomarker	<0.9	0.9 to 1.0	>1.0 to 1.4	p-value
C-reactive protein	2.91 (2.42, 3.51)	2.44 (2.15, 2.77)	2.19 (2.11, 2.28)	0.007
Interleukin-6	3.64 (3.21, 4.13)	3.09 (2.84, 3.37)	2.86 (2.78, 2.93)	0.0005
Fibrinogen	394 (381, 407)	372 (363, 381)	372 (369, 374)	0.005
Tumor necrosis factor alpha	1.43 (1.29, 1.58)	1.32 (1.24, 1.42)	1.25 (1.22, 1.27)	0.02
TNFR2	2258 (2142, 2379)	2087 (2013, 2164)	2009 (1987, 2030)	<0.0001

^*Biomarkers with P<0.05 displayed.

^†For each biomarker (dependent variable), we exponentiated the adjusted mean log-transformed biomarker and its 95% confidence interval to obtain its adjusted geometric mean and corresponding 95% confidence interval. Covariates in multivariable model include covariates listed in Table 3 legend.