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. Author manuscript; available in PMC: 2009 Nov 13.

Published in final edited form as: J Med Chem. 2008 Oct 11;51(21):6853–6865. doi: 10.1021/jm800967h

Scheme 13a — ^aReagents: (i) t-BuNO₂, CH₂I₂, CuI, THF, Δ; (ii) Allyl alcohol, Pd(OAc)₂, nBu₄NBr, NaHCO₃, DMF; (iii) morpholine, NaCNBH₃, MeOH, DMF; (iv) CF₃CO₃H, CF₃CO₂H, DCM; (v) Et₄Sn, Pd(PPh₃)₄, DME, Δ; (vi) NH₂CN, HCl, Δ; then 30% NaOH, Δ; (vii) NaNO₂, CF₃CO₂H; (viii) DMF, POCl₃, Δ.