Table 2.
Histological, biochemical and virological data on different therapy responses (mean ± SD)
| Parameter | HBeAg positive | HbeAg serocon -version | Sustained virological response | Virological flares |
| Number of patients | 48 | 17 | 18 | 30 |
| Mean Knodell score | ||||
| Pretreatment | 8.4 ± 4.1 | 7.1 ± 4.2 | 8.0 ± 4.0 | 8.4 ± 3.9 |
| Post-treatment | 6.0 ± 3.6 | 5.1 ± 3.1a | 6.1 ± 3.0 | 5.2 ± 2.7a |
| Mean ALT level (nkat/L) | ||||
| Pretreatment | 3206 ± 2338 | 3841 ± 2371 | 3340 ± 2638 | 4576 ± 2505 |
| Post-treatment | 1018 ± 985 | 618 ± 384a | 517 ± 300 | 601 ± 400 |
| 24 wk off- treatment | 851 ± 200 | 380 ± 183e | ||
| Serum HBV DNA (log10) | ||||
| Pretreatment | 7.9 ± 0.9 | 7.5 ± 1.0 | 7.3 ± 1.3 | 7.6 ± 0.8 |
| Post-treatment | 4.4 ± 1.4a | 3.0 ± 0.2ac | 3.1 ± 0.3a | 3.3 ± 0.4a |
| 24 wk off-treatment | 3.2 ± 0.3 | 6.1 ± 0.8ac | ||
| Intrahepatic HBV DNA (log10) | ||||
| Pretreatment | 6.3 ± 0.8 | 5.6 ± 1.2 | 5.9 ± 0.8 | 6.0 ± 1.1 |
| Post-treatment | 5.1 ± 1.5 | 4.1 ± 0.8a | 4.5 ± 1.6 | 4.3 ± 1.0a |
| Intrahepatic ccc DNA (log10) | ||||
| Pretreatment | 5.5 ± 1.1 | 5.8 ± 1.0 | 4.6 ± 1.0 | 5.4 ± 0.8e |
| Post-treatment | 3.9 ± 1.5 | 2.8 ± 1.3ac | 4.0 ± 0.9 | 3.8 ± 0.8a |
a
P < 0.05 vs post-treatment,
c
P < 0.05 vs HBeAg positive,
e
P < 0.05 vs sustained virological response. ALT: Alanine aminotransferase; ccc DNA: Covalently closed circular DNA.