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. 2009 Jun 11;4(6):e5788. doi: 10.1371/journal.pone.0005788

Figure 9. Representation of the newly identified genotypes of H9N2 viruses in poultry in Pakistan.

Figure 9

The possible genetic progenitors of these new genotypes are (A) H9N2 (LPAI) viruses represented by A/Ck/Pak/2/99, belonging to G1-lineage, (B) H9N2 (LPAI) viruses represented as Indian/Middle East lineage containing distinct polymerase complex genes, (C) H7N3 (HPAI) viruses represented by the prototype A/Ck/Pak/NARC-100/2004 virus, (D) H7N3 (HPAI) viruses represented by the prototype A/Ck/Pak/34668/95 virus containing a 13 amino acid deletion in their NS1 polypeptide and (E) H5N1 (HPAI) viruses represented by A/Ck/Afghanistan/1207/2006 belonging to genotype Z. The three newly identified H9N2 genotypes (F, G and H) contained PB2, PB1, and PA genes similar to an Indian/Middle East lineage of H9N2 virus, along with the NS genes derived from two distinct H7N3 parental viruses and an H5N1 parental virus and the HA, NA, NP and M genes from H9N2 viruses of the G1 lineage.