Figure 2. QKI-6 and QKI-7 induce the expression of Schwann cell differentiation markers and enhance their maturation.

Co-cultures of Schwann cells/neurons were transduced with control adenoviruses (Adv GFP, A and B), adenoviruses encoding QKI-6 (C and D), QKI-7 (E and F), or a combination of QKI-6/7 (G and H). Myelination was induced for 5 days with ascorbic acid and the culture stained with anti-MBP antibodies (red). (I) Parallel cultures were lysed and analyzed by immunoblotting for MBP, and β-actin was used to ensure equal loading. The relative band intensities quantified by densitometry are indicated below.