Table I.
Feed Composition, Drug Concentration, Enhancer Concentration (% w/v), CAP Concentration, % Yield of the Process, Theoretical Drug Content (TDC %), Actual Drug Content (ADC%) and Encapsulation Efficiency (EE %), d 50 (μm ± Standard Deviation) of all Microsystems Prepared
| Batches # | Feed composition | Drug concentration (% w/v) | Enhancer concentration (% w/v) | CAP concentration (% w/v) | Yield % | TDC % | ADC % | EE % | d50 μm (SD) |
|---|---|---|---|---|---|---|---|---|---|
| # 1a | CAP/Hd | 0.67 | – | 2.0 | 94.3 | 25.0 | 18.5 | 74.0 | 12.28 (0.07) |
| # 1b | CAP/Hd | 2.0 | – | 2.0 | 73.0 | 50.0 | 35.0 | 70.0 | 11.50 (0.12) |
| # 1c | CAP/Hd | 0.4 | – | 2.0 | 84.4 | 16.6 | 12.0 | 72.3 | 13.55 (0.10) |
| # 2 | CAP/Hd/CMC | 0.67 | 0.4 | 2.0 | 75.0 | 18.2 | 17.5 | 96.2 | 80.96 (2.40) |
| # 3 | CAP/Hd/SDBS | 0.67 | 0.5 | 2.0 | 93.0 | 21.0 | 17.0 | 80.9 | 43.18 (1.83) |
| # 4 | CAP/Hd/Tween | 0.67 | 0.5 | 2.0 | 76.0 | 21.0 | 18.9 | 90.0 | 42.86 (1.07) |
| # 5 | CAP blank | – | – | 2.0 | 100.0 | – | – | – | 3.90 (0.06) |
| # 6 | CAP/CMC | – | 0.4 | 2.0 | 90.0 | – | – | – | 35.86 (1.21) |
| # 7 | CAP/SDBS | – | 0.5 | 2.0 | 99.1 | – | – | – | 10.12 (0.64) |
| # 8 | CAP/Tween | – | 0.5 | 2.0 | 94.1 | – | – | – | 6.42 (0.51) |
| # 9 | Hd sd | 0.67 | – | – | 58.4 | 100.0 | 100.0 | – | 4.37 (0.12) |
| # 10 | Hd/CMC | 0.67 | 0.4 | – | 41.2 | 28.6 | 25.0 | 87.4 | 28.28 (0.20) |
| # 11 | Hd/SDBS | 0.67 | 0.5 | – | 88.0 | 57.1 | 29.7 | 52.0 | 19.96 (1.03) |
| # 12 | Hd/Tween | 0.67 | 0.5 | – | 65.2 | 57.1 | 28.0 | 49.0 | 21.76 (2.34) |
CAP cellulose acetate phthalate, CMC carboxymethylcellulose crosslinked, SDBS sodium dodecylbenzene sulfonate, Tween Tween 85, Hd Hesperidin, Hd sd, hesperidin spray-dried