Table I.
Formulation Composition of Matrix Tablets of Indomethacin
| Sr. | NoName of Ingredient | Quantity/tablet (mg) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Formulation codes | |||||||||||||
| F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | ||
| 01 | Indomethacin | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 |
| 02 | ChI | 5.375 | 10.75 | 16.125 | 5.375 | 10.75 | 16.125 | 5.375 | 10.75 | 16.125 | 21.5 | 21.5 | 21.5 |
| 03 | ChS | 5.375 | 10.75 | 16.125 | 5.375 | 10.75 | 16.125 | 5.375 | 10.75 | 16.125 | 21.5 | 21.5 | 21.5 |
| 04 | MCC (Emocel) | 121.375 | 105.2 | 89.125 | 121.375 | 105.25 | 89.125 | 121.375 | 105.25 | 89.125 | 89.125 | 83.75 | 78.375 |
| 05 | Ethyl Cellulose (10% Alcoholic Solution) | 5.375 | 10.75 | 16.125 | – | – | – | – | – | – | – | – | – |
| 06 | Starch paste (10%) | – | – | – | 5.375 | 10.75 | 16.125 | – | – | – | – | – | – |
| 07 | PVP K30 | – | – | – | – | – | – | 5.375 | 10.75 | 16.125 | 5.375 | 10.75 | 16.125 |
| 08 | Magnesium stearate | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 |
| Total weight of tablet | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | |
ChI chitosan, ChS chondroitin sulfate