Table II.
Characterization of Granules and Matrix Tablets of Indomethacin
| Parameters | Formulation Code | |||||
|---|---|---|---|---|---|---|
| F7 | F8 | F9 | F10 | F11 | F12 | |
| Granules | ||||||
| Angle of repose (deg) | 28 ± 1.1 | 25 ± 0.8 | 27 ± 0.9 | 22 ± 0.6 | 28 ± 1.2 | 27 ± 0.9 |
| Bulk Density (g/mL) | 0.68 | 0.57 | 0.46 | 0.53 | 0.43 | 0.41 |
| Tap Density (g/mL) | 0.78 | 0.65 | 0.53 | 0.61 | 0.50 | 0.48 |
| Carr’s Index | 13.0 ± 0.5 | 12.3 ± 0.5 | 13.2 ± 1.1 | 13.1 ± 0.6 | 14.0 ± 1.2 | 14.6 ± 1.1 |
| Total drug content (%) | 98.0 ± 3.6 | 98.5 ± 3.9 | 99.0 ± 3.7 | 98.2 ± 4.1 | 98.7 ± 3.8 | 99.1 ± 3.7 |
| Tablets | ||||||
| Weight variation (%) | ± 4.0 | ± 3.0 | ± 2.0 | ± 3.0 | ± 2.0 | ± 4.0 |
| Friability (%) | 0.24 | 0.32 | 0.11 | 0.22 | 0.19 | 0.17 |
| Hardness (kg/cm2) | 5.5 ± 0.1 | 5.7 ± 0.2 | 6.1 ± 0.4 | 5.7 ± 0.3 | 5.6 ± 0.4 | 6.3 ± 0.2 |
| Content uniformity (%) | 98.3 ± 4.3 | 98.7 ± 4.0 | 99.0 ± 0.5 | 98.4 ± 4.3 | 98.8 ± 4.0 | 99.3 ± 3.5 |
*All values represent mean ± SD (n = 3)