Table I.

Composition and Evaluation of Fluconazole Sprays

Ingredient (% w/w)	Batch code
	B1	B2	B3	B4	B5	B6
Fluconazole	0.5	0.5	0.5	0.5	0.5	0.5
Ethyl cellulose	3	5	7.5	–	–	–
Eudragit® RS100	–	–	–	5	10	15
PEG 400	0.25	0.25	0.25	0.25	0.25	0.25
Eutectic blend	10	10	10	10	10	10
Alcohol and acetone blend (q.s.)	100	100	100	100	100	100
Tests	Average results (n = 3)
Viscosity (a ± 2.7 cPs)	15.0	26.4	43.5	7.6	20.2	51.6
Volume of solution delivered upon each actuation (b ± 0.03 ml)	0.32	0.30	0.26	0.39	0.31	0.24
Spray angle (c ± 0.4°)	78.0	79.1	81.0	76.1	78.3	82.2
Y a1	21.07	17.07	12.55	23.44	14.12	11.73
Y b2	94	115	196	120	160	210
Ex–in vivo film formation timec (d ± 35 sec)	130	160	210	110	152	230
Feeling of warmth and subsequent cooling sensationc (e ± 1 min)	12	14	15	12	14	16
Appearance of the filmc	+	+	++	+	+	++
Dermal adhesion and flexibility of the filmc	++	++	++	++	+++	+++
Water washabilityc	++	++	++	+++	+++	++

^a Y ₁ is the amount of drug transported (μg) per ml at the end of first hour

^b Y ₂ is the time (min) required to transport 50% of the drug (t _50%)

^cMeasured for placebo batches replacing fluconazole with blend of alcohol and acetone