. 2009 May 22;10(2):684–691. doi: 10.1208/s12249-009-9256-8

Table II.

Composition and Evaluation of Fluconazole Sprays Based on 3² Full Factorial Design

Ingredient (% w/w)	Batch Code
Ingredient (% w/w)	B7	B8	B9	B10	B11	B12	B13	B14	B15	B16
Fluconazole	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Ethyl cellulose	7.5	5	3	7.5	5	3	7.5	5	3	5.25
Eudragit® RS100	15	15	15	10	10	10	5	5	5	10.6
PEG 400	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25	0.25
Eutectic blend	10	10	10	10	10	10	10	10	10	10
Alcohol and acetone blend (q.s.)	100	100	100	100	100	100	100	100	100	100
Tests	Average results (n = 3)
Viscosity (a ± 2.7 cPs)	128.3	92.8	70.8	69.7	48.9	38.1	52.5	34.0	23.7	52.9
Volume of solution delivered upon each actuation (b ± 0.03 ml)	0.14	0.18	0.2	0.21	0.26	0.31	0.26	0.3	0.33	0.24
Spray angle (c ± 0.4^o)	91.5	88.2	83.8	84.2	81.8	80.6	82.6	79.8	78.7	82.6
Ex–in vivo film formation time^a (d ± 35 sec)	532	435	390	372	328	287	340	282	249	335
Feeling of warmth and subsequent cooling sensation^a (e ± 1 min)	19	18	17	18	16	15	17	13	13	17
Appearance of the film^a	+++	++	++	++	++	+	++	+	+	++
Dermal adhesion and flexibility of the film^a	+++	+++	+++	+++	+++	+++	+++	++	++	+++
Water washability^a	+	+	++	++	++	++	++	++	++	++

^aMeasured for placebo batches replacing fluconazole with blend of alcohol and acetone