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. 2009 Jun 12;4(6):e5892. doi: 10.1371/journal.pone.0005892

Figure 2. Immuno-expression of RUNX3 in HNSCC.

Figure 2

A: Expression of RUNX3 was examined in skin epithelium (×100 and ×250, upper panel), normal oral mucosae (×100 and ×250, middle panel) and normal oral mucosae with infiltration of chronic inflammatory cells (×100 and ×250, lower panel). In skin epithelium, some of epidermal cells showed RUNX3 expression in its nuclei. In normal oral mucosal tissues, only a few epithelial cells in basal layer expressed RUNX3 in their nuclei, and most epithelial cells did not express RUNX3. In normal oral mucosae with infiltration of chronic inflammatory cells, lymphocytes infiltrating into oral mucosa showed RUNX3 expression. B: Expression of RUNX3 was examined in HNSCC cases (×100). Most cancer cells expressed RUNX3 in their nuclei.