Table 1. Runx3 expression in normal oral mucosa and HNSCC.

			Total	Runx3 expression Negative*	Runx3 expression Positive*	P value
Normal			9	9 (100%)	0 (0%)	0.005
HNSCC			52	26 (50%)	26 (50%)
HNSCC	Histology	Well	31	18 (58%)	13 (42%)	0.031
		Moderate	13	8 (62%)	5 (38%)
		Poorly	8	0 (0%)	8 (100%)
	Invasion**	I & II	26	18 (69%)	8 (31%)	0.006
		III & IV	26	8 (31%)	18 (69%)
	Metastasis	Negative	38	24 (63%)	14 (37%)	0.005
		Positive	14	2 (14%)	12 (86%)

^*Runx3 expression is graded as negative (less than 5% of positive cells) and positive (over 5% of positive cells).

^**The grading of invasion is according to the classification described by Jakobsson et al. as patterns I, II, III and IV [38].