Table 2. Distribution of LOXL1 polymorphisms in pseudoexfoliation and control subjects.
| SNP | Allele |
Allele count (frequency) |
Allele association (p value) | OR [95% CI] | Genotype |
Genotype count (frequency) |
Genotype association (p value) | p value OR [95% CI] | ||
|---|---|---|---|---|---|---|---|---|---|---|
| XFS/XFG Cases (n=62) | Controls (n=171) | XFS/XFG cases (n=62) | Controls (n=171) | |||||||
|
rs1048661 |
*G |
65 (0.524) |
152 (0.444) |
0.142 |
1.38
[0.91- 2.08] |
G-G |
20 (0.323) |
29 (0.169) |
0.03 |
0.0173**
2.33 [1.2–4.54] |
| T |
59 (0.476) |
190 (0.556) |
T-G |
25 (0.403) |
94 (0.550) |
|||||
| T-T |
17 (0.274) |
48 (0.281) |
||||||||
| rs3825942 | A |
1 (0.008) |
28 (0.082) |
0.0018 | 10.97 [1.48- 81.49] | G-G |
61 (0.984) |
143 (0.84) |
0.0013 | 0.0013 11.94 [1.59–89.78] |
| *G | 123 (0.992) | 314 (0.918) | G-A |
1 (0.016) |
28 (0.16) |
|||||
| A-A | 0 (0.00) | 0 (0.00) | ||||||||
Allelic and genotype association testing results of rs1048661 and rs3825942 in LOXL1 for Chinese cases with combined pseudoexfoliation syndrome and controls are shown. The single asterisk indicates the risk allele of each SNP. The double asterisk indicates the p values and OR values for G-G versus T-G+T-T of rs1048661. Abbreviations: SNP=single nucleotide polymorphism; XFS=pseudoexfoliation syndrome; XFG=pseudoexfoliation glaucoma; n=number of subjects; OR=odds ratio; CI=confidence interval.