Table 3. Haplotype analysis of LOXL1 polymorphisms in pseudoexfoliation and control subjects.
| rs1048661 | rs3825942 |
Haplotype frequency |
HS test* p value | OR* [95%CI] | p value** | OR** [95%CI] | |
|---|---|---|---|---|---|---|---|
| XFS/XFG total | Controls | ||||||
| T |
G |
0.476 |
0.556 |
0.124 |
1.39 [0.91–2.12] |
- |
- |
| G |
G |
0.516 |
0.363 |
0.0034 |
1.92 [1.25–2.96] |
0.018 |
1.7 [1.1–2.63] |
| G | A | 0.008 | 0.082 | 0.00039 | 0.08 [0.01–0.62] | 0.031 | 0.11 [0.01–0.80] |
All haplotypes with frequency greater than 1% in the combined case and control sample are shown in the table. The XFS/XFG total indicates pseudoexfoliation with and without glaucoma. The single asterisk indicates haplotype specific (HS) testing. This test is a comparison of a specific haplotype with the other two. The double asterisk indicates the p values and OR values derived from comparing each haplotype with the base-line haplotype (T-G). p values for HS testing are based on 10,000 permutations. Abbreviations: XFS=pseudoexfoliation syndrome; OR=odds ratio; CI=confidence interval; XFG=pseudoexfoliation glaucoma.