Table 4. Frequencies of the two-locus haplotype among three different populations.
| rs1048661 | rs3825942 |
Haplotype frequency |
|||||
|---|---|---|---|---|---|---|---|
|
Chinese |
Japanese [28] |
Caucasian [21] |
|||||
| XFS/XFG (n=62) | Controls (n=171) | XFS/XFG (n=209) | Controls (n=172) | XFS/XFG (n=86) | Controls (n=2087) | ||
| T |
G |
0.476 |
0.556 |
0.947 |
0.506 |
0.22 |
0.34 |
| G |
G |
0.516 |
0.363 |
0.039 |
0.365 |
0.74 |
0.51 |
| G |
A |
0.008 |
0.082 |
0.014 |
0.129 |
0.05 |
0.15 |
| Haplotype diversity (±SE) | 0.511 (± 0.01) | 0.554 (± 0.014) | 0.102 (±0.02) | 0.596 (± 0.014) | 0.404 (±0.037) | 0.602 (±0.004) | |
The two-locus haplotype frequencies in the Chinese, Japanese, and Caucasian are shown. Only one example is shown for Caucasians from a Caucasian Australian population for comparison with the two Asiatic populations. The distribution of the T-G, G-G, and G-A haplotypes were significantly different between cases and controls in both the Japanese and Caucasian studies shown here [21,28]. In our present Chinese study, only the G-G and G-A haplotypes were significantly different between cases and controls. Haplotype diversity is also given for each sample. Haplotype diversity is a measure of the uniqueness of a particular haplotype in a given population. The haplotype diversity and its variance were calculated using the formula given within the indicated reference [39].