Table 5. Reported allele frequencies of LOXL1 polymorphisms in pseudoexfoliation and control subjects among different populations.
| Population | Phenotype |
Allele frequency |
Sample size | References | |
|---|---|---|---|---|---|
|
rs1048661
(G/T) |
rs3825942
(G/A) |
||||
| G | G | ||||
| Iceland |
XFG |
0.827 |
0.987 |
75 |
[19] |
| Controls |
0.651 |
0.847 |
14474 |
||
| Sweden |
XFG |
0.834 |
0.995 |
199 |
[19] |
| Controls |
0.682 |
0.879 |
198 |
||
| USA Caucasian |
XFG |
0.787 |
0.939 |
50 |
[20] |
| Controls |
0.665 |
0.844 |
235 |
||
| Australia |
XFG, XFS |
0.78 |
0.95 |
86 |
[21] |
| Controls |
0.66 |
0.84 |
2087 |
||
| Europe (German+Italian) |
XFG, XFS |
0.82 |
0.965 |
726 |
[24] |
| Controls |
0.652 |
0.851 |
418 |
||
| Southern India |
XFG, XFS |
0.72 |
0.92 |
52 |
[26] |
| Controls |
0.63 |
0.74 |
97 |
||
| Japan |
XFG, XFS |
0.053 (T=0.947) |
0.99 |
209 |
[28] |
| Controls |
0.497 |
0.86 |
172 |
||
| Japan |
XFG |
0.005 (T=0.995) |
0.995 |
95 |
[30] |
| Controls |
0.47 |
0.85 |
190 |
||
| Singapore (Chinese) |
XFG, XFS |
0.524 |
0.992 |
62 |
Present study |
| Controls |
0.444 |
0.918 |
171 |
||
| Hong Kong (Chinese) |
Controls |
0.472 |
0.876 |
250 |
[34] |
| African American | Controls | NA | 0.599 | 97 | [31] |
Allele frequencies for the G alleles of rs1048661 and rs3825942 in pseudoexfoliation cases (with and without glaucoma) and controls among different populations are shown. The allele frequencies are shown for normal Chinese controls from Hong Kong for comparison with our present study. NA: not available.