Figure 2 Schematic of GIGYF2 gene (A) and amino acid/DNA sequence of GIGYF2 polymorphic exon 25 alleles (B)

(A) Schematic of GIGYF2 gene showing location of identified variants. The GIGYF2 gene structure is depicted approximately to scale with the exons numbered above the gene. Below the gene are shown variants identified in patients with PD. Those in boxes represent the three novel variants of this report while the remaining seven were previously published. (B) Amino acid/DNA sequence of GIGYF2 polymorphic exon 25 alleles. At top is shown the amino acid sequence corresponding to the 3′ portion of exon 25 encoding residues 1200 to 1228 (numbers above amino acid sequence). Shown directly below the amino acid sequence are the eight different alleles identified in our study sample. Numbers at left designate allele sizes (bp) by fluorescent genotyping. The 160 bp allele is the normal reference allele based on the GenBank sequence. All other alleles are shown relative to the normal 160 bp allele. Missing residues are depicted as underlined gaps in the sequence. The QQ insertion at residue 1217 in allele 163 is indicated by the underlined CAG codons occurring between codons 1216 and 1217 in the normal sequence.