TABLE 1.
Distribution of IL-10 (−1087A/G and −597C/A), TNF-α (−308G/A), and IFN-γ (+874T/A) SNP genotype frequencies in 80 MSF patients and 288 healthy controls
| SNP | Genotypes | Patients
|
Controls
|
OR (95% CI) | P | ||
|---|---|---|---|---|---|---|---|
| n | Frequency (%) | n | Frequency (%) | ||||
| IL-10 −1087G/A | GG | 17 | 21.2 | 67 | 23.3 | 0.89 (0.49-1.62) | 0.82 |
| GA | 40 | 50.0 | 135 | 46.9 | 1.13 (0.69-1.86) | 0.71 | |
| AA | 23 | 28.8 | 86 | 29.9 | 0.95 (0.55-1.64) | 0.96 | |
| IL-10 −597C/A | CC | 43 | 53.8 | 152 | 52.8 | 1.04 (0.63-1.71) | 0.98 |
| CA | 31 | 38.7 | 106 | 36.8 | 1.09 (0.65-1.81) | 0.85 | |
| AA | 6 | 7.5 | 30 | 10.4 | 0.70 (0.28-1.74) | 0.57 | |
| TNF-α −308G/A | GG | 60 | 75 | 209 | 72.6 | 1.13 (0.64-2.02) | 0.77 |
| GA | 19 | 23.8 | 73 | 25.3 | 0.92 (0.51-1.64) | 0.88 | |
| AA | 1 | 1.2 | 6 | 2.1 | 0.60 (0.07-5.02) | 0.98 | |
| IFN-γ +874T/Aa | TT | 4 | 5.0 | 65 | 22.6 | 0.18 (0.06-0.51) | 0.0007 |
| TA | 51 | 63.8 | 154 | 53.5 | 1.53 (0.92-2.55) | 0.13 | |
| AA | 25 | 31.2 | 69 | 23.9 | 1.44 (0.84-2.50) | 0.24 | |
a
The nonparametric Mantel-Haenszel procedure was applied for comparisons of IFNγ +874 genotype frequencies, as the MSF patient group did not fit to Hardy-Weinberg equilibrium. As multiple comparisons were made, Bonferroni's correction was applied to a significant P value that was multiplied by the number of genotypes (three) detected (Pc = 0.0021).