TABLE 2.
Distribution of IFN-γ (+874T/A) and IL-10 (−1087A/G or −597C/A) SNP combined genotypes in 80 MSF patients and 288 healthy controls
| Genotypes
|
Patients
|
Controls
|
OR (95% CI) | Pca | |||
|---|---|---|---|---|---|---|---|
| IFN-γ | IL-10 | n | Frequency (%) | n | Frequency (%) | ||
| +874TT | −1087GG | 1 | 1.25 | 17 | 5.90 | 0.20 (0.03-1.54) | >1.00 |
| −1087GA | 2 | 2.50 | 37 | 12.84 | 0.17 (0.04-0.74) | 0.32 | |
| −1087AA | 1 | 1.25 | 11 | 3.80 | 0.32 (0.04-2.54) | >1.00 | |
| −597CC | 1 | 1.25 | 41 | 14.20 | 0.08 (0.01-0.57) | 0.060 | |
| −597CA | 2 | 2.50 | 22 | 7.60 | 0.31 (0.07-1.35) | >1.00 | |
| −597AA | 1 | 1.25 | 2 | 0.70 | 1.83 (0.16-20.50) | >1.00 | |
| +874TA | −1087GG | 12 | 15.00 | 32 | 11.10 | 1.41 (0.69-2.89) | >1.00 |
| −1087GA | 24 | 30.00 | 62 | 21.53 | 1.562 (0.90-2.72) | >1.00 | |
| −1087AA | 15 | 18.75 | 60 | 20.80 | 0.88 (0.47-1.65) | >1.00 | |
| −597CC | 34 | 42.50 | 70 | 24.30 | 2.30 (1.37-3.87) | 0.051 | |
| −597CA | 14 | 17.50 | 76 | 26.40 | 0.59 (0.31-1.12) | >1.00 | |
| −597AA | 3 | 3.75 | 12 | 4.20 | 0.90 (0.25-3.26) | >1.00 | |
| +874AA | −1087GG | 4 | 5.00 | 18 | 6.25 | 0.79 (0.26-2.40) | >1.00 |
| −1087GA | 14 | 17.50 | 36 | 12.50 | 1.49 (0.76-2.91) | >1.00 | |
| −1087AA | 7 | 8.75 | 15 | 5.20 | 1.75 (0.69-4.44) | >1.00 | |
| −597CC | 8 | 10.00 | 41 | 14.20 | 0.67 (0.30-1.49) | >1.00 | |
| −597CA | 15 | 18.75 | 12 | 4.20 | 5.31 (2.37-11.88) | 0.0027 | |
| −597AA | 2 | 2.50 | 16 | 5.50 | 0.44 (0.10 to 1.94) | >1.00 | |
a
Comparisons among the different combined genotype frequencies were performed by applying the nonparametric Mantel-Haenszel procedure. As multiple comparisons were made, Bonferroni's correction was applied to P values that were multiplied by the number of genotypes (27) involved in the analyses.