TABLE 1.
In vitro antifungal agent susceptibilities of Candida and Cryptococcus isolates collected by the SENTRY Program in 2006 to 2007
| Species (no. of isolates) and drug | MIC50/MIC90 (μg/ml) | MIC range (μg/ml) | % by categorya
|
||
|---|---|---|---|---|---|
| S | SDD | Rb | |||
| All Candida spp. (1,448)c | |||||
| Anidulafungin | 0.03/1 | 0.002-4 | 99.0 | — | 1.0 |
| Caspofungin | 0.12/0.5 | 0.03->16 | 99.8 | — | 0.2 |
| Amphotericin B | 0.5/1 | ≤0.12-2 | 99.6 | — | 0.4 |
| 5-FC | ≤0.5/1 | ≤0.5->64 | 95.9 | (2.2) | 1.9 |
| Fluconazole | ≤0.5/8 | ≤0.5->64 | 93.4 | 4.7 | 1.9 |
| Itraconazole | 0.06/0.5 | ≤0.015->2 | 67.9 | 20.6 | 11.5 |
| Posaconazole | ≤0.06/1 | ≤0.06->8 | — | — | — |
| Voriconazole | ≤0.06/0.5 | ≤0.06-8 | 98.3 | 0.8 | 0.9 |
| C. albicans (771) | |||||
| Anidulafungin | 0.015/0.06 | 0.002-1 | 100.0 | — | 0.0 |
| Caspofungin | 0.12/0.25 | 0.03-1 | 100.0 | — | 0.0 |
| Amphotericin B | 0.5/1 | ≤0.12-1 | 100.0 | — | 0.0 |
| 5-FC | ≤0.5/1 | ≤0.5->64 | 97.9 | (0.1) | 2.0 |
| Fluconazole | ≤0.5/≤0.5 | ≤0.5-16 | 99.7 | 0.3 | 0.0 |
| Itraconazole | 0.03/0.06 | ≤0.015-1 | 97.7 | 2.0 | 0.3 |
| Posaconazole | ≤0.06/0.12 | ≤0.06-1 | — | — | — |
| Voriconazole | ≤0.06/≤0.06 | ≤0.06-0.25 | 100.0 | 0.0 | 0.0 |
| C. parapsilosis (238) | |||||
| Anidulafungin | 2/2 | 0.03-4 | 95.4 | — | 4.6 |
| Caspofungin | 0.5/1 | 0.06-4 | 99.6 | — | 0.4 |
| Amphotericin B | 1/1 | 0.25-1 | 99.6 | — | 0.4 |
| 5-FC | ≤0.5/≤0.5 | ≤0.5->64 | 98.7 | (0.0) | 1.3 |
| Fluconazole | 1/4 | ≤0.5-32 | 96.6 | 3.4 | 0.0 |
| Itraconazole | 0.25/0.5 | ≤0.015-2 | 40.8 | 57.1 | 2.1 |
| Posaconazole | 0.12/0.25 | ≤0.06-1 | — | — | — |
| Voriconazole | ≤0.06/0.12 | ≤0.06-2 | 99.6 | 0.4 | 0.0 |
| C. glabrata (202) | |||||
| Anidulafungin | 0.015/0.12 | 0.015-1 | 100.0 | — | 0.0 |
| Caspofungin | 0.25/0.25 | 0.06-2 | 100.0 | — | 0.0 |
| Amphotericin B | 1/1 | ≤0.12-1 | 100.0 | — | 0.0 |
| 5-FC | ≤0.5/≤0.5 | ≤0.5 | 100.0 | (0.0) | 0.0 |
| Fluconazole | 8/64 | ≤0.5->64 | 74.3 | 15.3 | 10.4 |
| Itraconazole | 1/>2 | ≤0.015->2 | 3.5 | 26.7 | 69.8 |
| Posaconazole | 1/4 | ≤0.06->8 | — | — | — |
| Voriconazole | 0.25/1 | ≤0.06-8 | 90.1 | 3.5 | 6.4 |
| C. tropicalis (157) | |||||
| Anidulafungin | 0.03/0.06 | 0.008-0.5 | 100.0 | — | 0.0 |
| Caspofungin | 0.12/0.5 | 0.06-2 | 100.0 | — | 0.0 |
| Amphotericin B | 1/1 | ≤0.12-2 | 98.1 | — | 1.9 |
| 5-FC | ≤0.5/≤0.5 | ≤0.5->64 | 94.9 | (0.6) | 4.5 |
| Fluconazole | ≤0.5/1 | ≤0.5-32 | 99.4 | 0.6 | 0.0 |
| Itraconazole | 0.12/0.5 | 0.03->2 | 65.6 | 30.6 | 3.8 |
| Posaconazole | 0.12/0.25 | ≤0.06->8 | — | — | — |
| Voriconazole | ≤0.06/≤0.06 | ≤0.06-0.5 | 98.1 | 0.6 | 1.3 |
| C. krusei (29) | |||||
| Anidulafungin | 0.06/0.5 | 0.03-2 | 100.0 | — | 0.0 |
| Caspofungin | 0.5/1 | 0.25-4 | 96.6 | — | 3.4d |
| Amphotericin B | 1/1 | 0.25-2 | 93.1 | — | 6.9 |
| 5-FC | 16/16 | 4-32 | 3.4 | (93.2) | 3.4 |
| Fluconazole | 32/64 | 8->64 | 3.5 | 79.3 | 17.2 |
| Itraconazole | 0.5/1 | 0.25->2 | 0.0 | 79.3 | 20.7 |
| Posaconazole | 0.5/1 | ≤0.06-1 | — | — | — |
| Voriconazole | 0.25/1 | 0.12-2 | 93.1 | 6.9 | 0.0 |
| C. lusitaniae (14) | |||||
| Anidulafungin | 0.25/0.5 | 0.12-0.5 | 100.0 | — | 0.0 |
| Caspofungin | 0.5/0.5 | 0.25-1 | 100.0 | — | 0.0 |
| Amphotericin B | 0.5/0.5 | ≤0.12-0.5 | 100.0 | — | 0.0 |
| 5-FC | ≤0.5/≤0.5 | ≤0.5 | 100.0 | (0.0) | 0.0 |
| Fluconazole | ≤0.5/1 | ≤0.5-32 | 92.9 | 7.1 | 0.0 |
| Itraconazole | 0.12/0.5 | 0.03-1 | 64.3 | M28.6 | 7.1 |
| Posaconazole | ≤0.06/0.12 | ≤0.06-0.25 | — | — | — |
| Voriconazole | ≤0.06/≤0.06 | ≤0.06-0.25 | 100.0 | 0.0 | 0.0 |
| C. neoformans (33) | |||||
| Anidulafungin | >32/>32 | 8->32 | — | — | — |
| Caspofungin | 16/16 | 4-16 | — | — | — |
| Amphotericin B | 0.25/0.25 | ≤0.12-0.5 | — | — | — |
| 5-FC | 4/8 | 2-16 | — | — | — |
| Fluconazole | 4/8 | 1-32 | — | — | — |
| Itraconazole | 0.06/0.25 | ≤0.015-0.25 | — | — | — |
| Posaconazole | ≤0.06/0.12 | ≤0.06-0.5 | — | — | — |
| Voriconazole | ≤0.06/0.12 | ≤0.06-0.5 | — | — | — |
The breakpoint criteria used are those of the CLSI (2008). When testing amphotericin B, a susceptibility breakpoint of ≤1 μg/ml was used. Each value in parentheses is the percent intermediate (CLSI, 2008), and a dash indicates that there is no established breakpoint.
There is no resistant category for echinocandins. The CLSI interpretive guidelines state that strains with echinocandin MICs of ≤2.0 μg/ml are susceptible. MICs of >2.0 μg/ml result in classification as not susceptible.
Data are not shown for C. dubliniensis (seven isolates), C. famata (six isolates), C. guilliermondii (nine isolates), C. kefyr (five isolates), C. pelliculosa (four isolates), and four Candida sp. isolates plus two unspecified isolates.
Represents a single isolate.