TABLE 2.
Clinical strains with low-level isoniazid resistance
| Strain | Method | Susceptibility to the following drug at the indicated concn (mg/liter):
|
Genetic resistance | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Isoniazid
|
Ethionamide
|
|||||||||||
| 0.1 | 0.4 | 1.0 | 3.0 | 10.0 | 1.25 | 2.5 | 5.0 | 12.5 | 25.0 | |||
| TBC 2694 | Bactec 460 | R | S | S | S | S | R | R | NDa | S | S | katG, wtb; inhA, C15T |
| MGIT 960 | R | I | I | S | S | R | R | R | I | S | ||
| TBC 4269 | Bactec 460 | R | S | S | S | S | R | R | R | R | R | katG, wt; inhA, C15T |
| MGIT 960 | R | I | I | S | S | R | R | R | R | R | ||
| NZM 117 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | S | S | ||
| NZM 150 | Bactec 460 | R | S | S | S | S | R | R | R | R | ND | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | R | I | ||
| NZM 188 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | S | S | ||
| TBC 2339 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | S | S | S | S | R | R | R | R | I | ||
| TBC 179320 | Bactec 460 | R | S | S | S | S | R | R | R | R | ND | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | R | R | ||
| TBC 179987 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | S | S | S | S | R | R | R | S | S | ||
| NZM 186008 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | S | S | S | S | R | R | R | S | S | ||
| NZM 186016 | Bactec 460 | R | S | S | S | S | R | R | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | S | S | ||
| TBC 176592 | Bactec 460 | R | S | S | S | S | R | S | ND | S | S | katG, wt; inhA, C15T |
| MGIT 960 | R | I | S | S | S | R | R | R | S | S | ||
a
ND, not done.
b
wt, wild type.