TABLE 3.
Clinical M. tuberculosis strains with drug resistance: first-line drugs
| Strain | Method | Isoniazid
|
Rifampin
|
Ethambutol
|
Streptomycin
|
|||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Susceptibility at the following concn (mg/liter):
|
Genetic resistance | Susceptibility at the following concn (mg/liter):
|
Genetic resistance | Susceptibility at the following concn (mg/liter):
|
Genetic resistance | Susceptibility at the following concn (mg/liter):
|
Genetic resistance | |||||||||||||||||
| 0.1 | 0.4 | 1 | 3 | 10 | 1 | 3 | 10 | 50 | 2.5 | 5 | 12.5 | 25 | 50 | 1 | 4 | 10 | 20 | 50 | ||||||
| NZM 130 | Bactec 460 | R | R | R | R | R | katG, S315T1d; inhA, wtb | R | R | R | R | S531L | R | R | NDa | ND | S | embB codon 306, wt (ATG) | R | ND | S | S | S | rpsL pos.c 42, AAG (wt); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | I | R | R | R | R | R | I | S | S | ND | R | S | S | S | S | |||||
| NZM 179 | Bactec 460 | R | R | R | R | R | katG, wt; inhA, C15T | R | R | R | R | S531L plus 2nd mutation | R | R | R | ND | S | embB codon 306, CTG (valine) | R | R | R | R | R | rpsL pos. 42, AGG (Arg); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | R | R | R | R | R | R | R | I | S | ND | R | R | R | R | ND | |||||
| NZM 186006 (NZM 154/04) | Bactec 460 | R | R | R | S | S | katG, wt; inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, ATA (isoleucine) | R | R | R | R | R | rpsL pos. 42, AGG (Arg); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | I | S | R | R | R | R | R | R | S | S | ND | R | R | R | R | ND | |||||
| NZM 186137 (NZM 152/04) | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, wt (ATG) | R | R | R | R | R | rpsL pos. 42, AGG (Arg); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | I | R | R | R | R | R | R | I | S | ND | R | R | R | R | ND | |||||
| TBC 6893 | Bactec 460 | R | R | R | S | S | katG, S315T1; inhA, wt | R | S | S | S | wt | S | S | S | ND | S | embB codon 306, wt (ATG) | R | ND | S | S | S | rpsL pos. 42, AAG (wt); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | I | S | R | S | S | S | S | S | S | S | ND | R | R | ND | S | S | |||||
| TBC 3106 | Bactec 460 | R | R | R | R | S | katG, wt; inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, wt (ATG) | S | S | S | S | S | ND |
| MGIT 960 | R | R | R | I | S | R | R | R | R | R | R | S | S | ND | S | S | S | S | S | |||||
| NZM 186038 (NZM 3/05) | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, ATC (isoleucine) | R | R | R | R | R | rpsL pos. 42, AGG (Arg); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | I | R | R | R | R | R | R | S | S | ND | R | R | R | R | ND | |||||
| TBC 176291 | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | R | R | R | R | H526D | R | S | S | ND | S | embB codon 306, wt (ATG) | R | ND | S | S | S | rpsL pos. 42, AAG (wt); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | I | S | R | R | R | R | R | S | S | S | ND | R | S | S | S | S | |||||
| TBC 177836 | Bactec 460 | R | R | R | R | R | katG, S315T1; inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, wt (ATG) | R | R | R | S | S | rpsL pos. 42, AAG (wt); pos. 87, AGG (Arg) |
| MGIT 960 | R | R | R | R | R | R | R | R | R | R | R | I | S | ND | R | R | R | S | S | |||||
| TBC 181783 | Bactec 460 | R | R | R | S | S | katG, wt; inhA, C15T | R | R | R | R | S531L | R | R | R | ND | S | embB codon 306, GTG (valine) | R | ND | S | S | S | rpsL pos. 42, AAG (wt); pos. 87, AGG (Arg) |
| MGIT 960 | R | R | R | I | S | R | R | R | R | R | R | R | R | S | R | R | ND | I | ND | |||||
| NZM 186069 | Bactec 460 | R | R | R | S | S | katG, S315T1, inhA, wt | R | R | R | R | S531L | R | R | S | ND | S | embB codon 306, ATA (isoleucine) | R | ND | S | S | S | rpsL pos. 42, AAG (wt); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | S | R | R | R | R | R | I | S | S | ND | R | S | S | S | S | |||||
| TBC 6890 | Bactec 460 | R | R | R | S | S | katG, S315T1; inhA, wt | R | R | R | R | S531L | S | S | S | ND | S | embB codon 306, wt (ATG) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | I | S | R | ND | ND | ND | S | S | S | S | ND | ND | ND | ND | ND | ND | |||||
| TBC 7392 | Bactec 460 | R | R | R | S | S | katG, S315T1; inhA, wt | S | S | S | S | wt | S | S | S | ND | S | embB codon 306, wt (ATG) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | I | S | S | ND | ND | ND | S | S | S | S | ND | ND | ND | ND | ND | ND | |||||
| TBC 295 | Bactec 460 | R | R | R | R | R | katG, S315T1; inhA, wt | R | R | R | R | S531L | R | S | S | ND | S | embB codon 306, ATA (isoleucine) | R | R | R | R | R | rpsL pos. 42, AGG (Arg); pos. 87, AAG (wt) |
| MGIT 960 | R | R | R | R | R | R | ND | ND | ND | R | I | S | S | ND | ND | ND | ND | ND | ND | |||||
| TBC 179882 | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | S | S | S | S | wt | S | S | S | ND | S | embB codon 306, wt (ATG) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | R | S | S | ND | ND | ND | S | S | S | S | ND | ND | ND | ND | ND | ND | |||||
| NZM 186073 | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | S | S | S | S | ND | S | S | S | ND | S | embB codon 306, wt (ATG) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | R | I | S | ND | ND | ND | S | S | S | S | ND | ND | ND | ND | ND | ND | |||||
| NZM 186044 | Bactec 460 | R | R | R | R | R | katG, S315T1; inhA, C15T | ND | ND | ND | ND | ND | R | S | S | ND | S | embB codon 306, ATA (isoleucine) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | R | R | ND | ND | ND | ND | R | S | S | S | ND | ND | ND | ND | ND | ND | |||||
| NZM 178364 | Bactec 460 | R | R | R | R | S | katG, S315T1; inhA, wt | S | S | S | S | wt | S | S | S | ND | S | embB codon 306, wt (ATG) | ND | ND | ND | ND | ND | ND |
| MGIT 960 | R | R | R | R | S | ND | ND | ND | ND | S | S | S | S | ND | ND | ND | ND | ND | ND | |||||
a
ND, not done.
b
wt, wild type.
c
pos., position.
d
Corresponds to an AGC to ACC substitution.