. 2009 Apr 1;47(6):1773–1780. doi: 10.1128/JCM.02501-08

TABLE 4.

Clinical M. tuberculosis strains with drug resistance: second line drugs

Strain	Method	Ethionamide						Amikacin						Susceptibility to the following drug at the indicated concn (mg/liter):
		Susceptibility at the following concn (mg/liter):					Genetic resistance	Susceptibility at the following concn (mg/liter):					Genetic resistance	Ofloxacin				Linezolid			Capreomycin
		1.25	2.5	5	12.5	25	Genetic resistance	1	4	10	20	50	Genetic resistance	2	10	20	50	0.4	1	4	1.25	5	25
NZM 130	Bactec 460	R	R	ND^a	S	S	inhA, wt^b	S	ND	S	ND	S	ND	S	S	S	ND	S	ND	S	ND	ND	ND
NZM 130	MGIT 960	R	R	R	R	S	inhA, wt^b	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	I	S	S
NZM 179	Bactec 460	R	R	R	R	ND	inhA, C15T	S	ND	S	ND	S	ND	S	S	S	ND	S	ND	S	ND	S	ND
NZM 179	MGIT 960	R	R	R	R	I	inhA, C15T	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	I	S	S
NZM 186006 (NZM 154/04)	Bactec 460	ND	ND	ND	ND	ND	inhA, wt	S	ND	S	ND	S	ND	S	S	S	ND	R	ND	S	ND	S	ND
NZM 186006 (NZM 154/04)	MGIT 960	ND	ND	ND	ND	ND	inhA, wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	I	S	S
NZM 186137 (NZM 152/04)	Bactec 460	R	R	ND	S	ND	inhA, wt	R	ND	R	ND	R	rrn, A1408G	S	S	S	ND	R	ND	S	ND	S	ND
NZM 186137 (NZM 152/04)	MGIT 960	R	R	R	R	R	inhA, wt	R	R	ND	R	ND	rrn, A1408G	S	S	ND	S	ND	S	S	R	ND	S
TBC 6893	Bactec 460	S	S	S	S	S	inhA, wt	S	ND	S	ND	S	ND	S	S	S	ND	S	ND	S	ND	ND	ND
TBC 6893	MGIT 960	ND	S	S	S	S	inhA, wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	R	S	S
TBC 3106	Bactec 460	S	S	ND	S	S	inhA, wt	S	ND	S	ND	S	ND	S	S	S	ND	S	ND	S	ND	S	ND
TBC 3106	MGIT 960	ND	S	ND	S	S	inhA, wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	S	S	S
NZM 186038 (NZM 3/05)	Bactec 460	R	R	ND	S	S	inhA, wt	S	ND	S	ND	S	ND	S	S	S	ND	R	ND	S	ND	S	ND
NZM 186038 (NZM 3/05)	MGIT 960	R	R	R	I	S	inhA, wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	S	S	S
TBC 176291	Bactec 460	ND	ND	ND	ND	ND	inhA, wt	S	ND	S	ND	S	ND	S	S	S	ND	ND	ND	ND	ND	ND	ND
TBC 176291	MGIT 960	ND	ND	ND	ND	ND	inhA, wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	S	S	S
TBC 177836	Bactec 460	R	R	ND	S	S	inhA: wt	S	ND	S	ND	S	ND	S	S	S	ND	S	ND	S	ND	S	ND
TBC 177836	MGIT 960	R	R	R	R	R	inhA: wt	S	S	ND	S	ND	ND	S	S	ND	S	ND	S	S	S	S	S
TBC 181783	Bactec 460	R	R	R	R	ND	inhA: C15T	S	ND	S	ND	S	ND	R	S	S	ND	R	ND	S	ND	S	ND
TBC 181783	MGIT 960	R	R	R	R	R	inhA: C15T	S	S	ND	S	ND	ND	R	S	ND	S	ND	S	S	S	S	S
NZM 186069	Bactec 460	ND	ND	ND	ND	ND	inhA: wt	S	ND	S	ND	S		S	S	S	ND	R	ND	S	ND	S	ND
NZM 186069	MGIT 960	ND	ND	ND	ND	ND	inhA: wt	S	S	ND	S	ND		S	S	ND	S	ND	S	S	R	S	S
TBC 6890	Bactec 460	S	S	S	S	S	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
TBC 6890	MGIT 960	ND	S	S	S	S	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
TBC 7392	Bactec 460	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
TBC 7392	MGIT 960	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
TBC 295	Bactec 460	R	R	R	R	ND	inhA: wt	S	ND	S	ND	S	ND	S	S	S	S	S	ND	S	ND	ND	ND
TBC 295	MGIT 960	R	R	R	R	R	inhA: wt	S	S	ND	S	ND	ND	S	S	S	S	ND	S	S	S	S	S
TBC 179882	Bactec 460	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
TBC 179882	MGIT 960	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 186073	Bactec 460	S	S	S	S	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 186073	MGIT 960	S	S	S	S	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 186044	Bactec 460	R	S	S	S	ND	inhA: C15T	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 186044	MGIT 960	R	R	R	S	S	inhA: C15T	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 178364	Bactec 460	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND
NZM 178364	MGIT 960	ND	ND	ND	ND	ND	inhA: wt	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND	ND

ND, not done.

wt, wild type.