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Effect of p27 genotype on breast tumor latency. The percentage of mice that developed breast cancer is plotted versus age in weeks. (A) Intact B6129 Wnt-1 female mice of the indicated p27 genotypes. (B) Intact B6129 Wnt-1 male mice of the indicated p27 genotypes. (C) Ovariectomized, estrogen and P-supplemented B6129 Wnt-1 female mice of the indicated p27 genotypes. (D) Kaplan–Meier survival analysis of Wnt-1 p27−/− mice versus Wnt-1 p27−/− ovariectomized and implanted with E + P.
