Table II.
Association between genotypes of the selected NER SNPs and SPM risk in a recessive genetic model
| Genotypes | Total |
SPM |
SPM free |
P-value | Adjusted HRa (95% CI) | |||
| N | % | n | % | n | % | |||
| ERCC1 C8092A | ||||||||
| CC and CA | 1000 | 93.7 | 102 | 93.6 | 898 | 93.7 | 0.948 | 1.0 |
| AA | 67 | 6.3 | 7 | 6.4 | 60 | 6.3 | 0.9 (0.4–1.9) | |
| XPA G23A | ||||||||
| GG and GA | 767 | 86.3 | 97 | 89.0 | 670 | 85.9 | 0.379 | 1.0 |
| AA | 122 | 13.7 | 12 | 11.0 | 110 | 14.1 | 0.7 (0.4–1.3) | |
| XPC Ala499Val | ||||||||
| Ala/Ala and Ala/Val | 757 | 90.2 | 98 | 89.9 | 659 | 90.3 | 0.905 | 1.0 |
| Val/Val | 82 | 9.8 | 11 | 10.1 | 71 | 9.7 | 0.7 (0.4–1.4) | |
| XPC Lys939Gln | ||||||||
| Lys/Lys and Lys/Gln | 821 | 85.6 | 94 | 86.2 | 727 | 85.5 | 0.843 | 1.0 |
| Gln/Gln | 138 | 14.4 | 15 | 13.8 | 123 | 14.5 | 0.9 (0.5–1.5) | |
| XPD Asp312Asn | ||||||||
| Asp/Asp and Asp/Asn | 1086 | 87.2 | 100 | 90.9 | 986 | 86.8 | 0.218 | 1.0 |
| Asn/Asn | 160 | 12.8 | 10 | 9.1 | 150 | 13.2 | 0.7 (0.4–1.4) | |
| XPD Lys751Gln | ||||||||
| Lys/Lys and Lys/Gln | 1126 | 88.0 | 95 | 86.4 | 1031 | 88.1 | 0.588 | 1.0 |
| Gln/Gln | 154 | 12.0 | 15 | 13.6 | 139 | 11.9 | 1.1 (0.6–1.9) | |
| XPG His1104Asp | ||||||||
| His/His and His/Asp | 819 | 95.6 | 104 | 95.4 | 715 | 95.6 | 0.934 | 1.0 |
| Asp/Asp | 38 | 4.4 | 5 | 4.6 | 33 | 4.4 | 1.1 (0.4–2.6) | |
a
Adjusted for age, sex, ethnicity, smoking and alcohol.