Table III.
Association between genotypes of selected NER SNPs and SPM risk in a recessive genetic model stratified by SPM type
| SCCHN SPM |
SCCHN or other tobacco-associated SPM |
Non-tobacco-associated SPM |
|
| HRa (95% CI) | HRa (95% CI) | HRa (95% CI) | |
| ERCC1 C8092A | |||
| CC and CA | 1.0 | 1.0 | 1.0 |
| AA | 0.6 (0.1–2.5) | 0.7 (0.3–1.9) | 1.2 (0.4–3.9) |
| XPA G23A | |||
| GG and GA | 1.0 | 1.0 | 1.0 |
| AA | 0.8 (0.3–1.8) | 0.6 (0.3–1.3) | 0.7 (0.2–2.0) |
| XPC Ala499Val | |||
| Ala/Ala and Ala/Val | 1.0 | 1.0 | 1.0 |
| Val/Val | 0.4 (0.1–1.3) | 0.8 (0.4–1.6) | 0.5 (0.2–1.8) |
| XPC Lys939Gln | |||
| Lys/Lys and Lys/Gln | 1.0 | 1.0 | 1.0 |
| Gln/Gln | 0.9 (0.4–2.3) | 0.8 (0.4–1.6) | 0.9 (0.3–2.6) |
| XPD Asp312Asn | |||
| Asp/Asp and Asp/Asn | 1.0 | 1.0 | 1.0 |
| Asn/Asn | 0.8 (0.3–2.1) | 0.9 (0.4–1.8) | 0.5 (0.1–1.9) |
| XPD Lys751Gln | |||
| Lys/Lys and Lys/Gln | 1.0 | 1.0 | 1.0 |
| Gln/Gln | 0.6 (0.2–1.9) | 1.0 (0.5–1.9) | 1.2 (0.5–3.2) |
| XPG His1104Asp | |||
| His/His and His/Asp | 1.0 | 1.0 | 1.0 |
| Asp/Asp | 0.5 (0.1–3.6) | 0.4 (0.0–2.6) | 2.4 (0.8–7.1) |
a
Adjusted for age, sex, ethnicity, smoking and alcohol.