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Dose Escalation Schedule
| Stratum A1 | Stratum B2 | |||||
|---|---|---|---|---|---|---|
| Dose Level | Vatalinib (mg/day) | Imatinib (mg/day) | Hydroxyurea (mg bid) | Vatalinib (mg/day) | Imatinib (mg bid) | Hydroxyurea (mg bid) |
| 1 | 500 | 400 | 500 | 750 | 500 | 500 |
| 2 | 750 | 1000 | ||||
| 3 | 1000 | 1250 | ||||
Stratum A: patients not on CYP3-A inducing anti-epileptics (EIAEDs: phenytoin, phenobarbitol, carbamazepine, oxcarbazepine, primidone)
Stratume B: patients on EIAEDs
