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. 2009 Jan 23;64A(1):47–60. doi: 10.1093/gerona/gln021

Table 1.

Summary of Chronic Disease-Related Genes With a Relationship to Aging and Longevity in Human Studies

Gene Cited Polymorphism Association with Longevity
Chronic Disease*
Evidence For Evidence Against
ACE intron16ins/del (28, 29, 5355) (27, 5661) CVD, AD
AGT M235T (25, 61) CVD
APOA1 G-75A (62) CVD/lipid metabolism
APOA4 Gln360His (63) CVD/lipid metabolism
Asp127Ser (62)
APOB 3′-APOB VNTR allele (6467) (28, 30, 68) CVD/lipid metabolism
Haplotype (67)
APOC1 HpaI site (54) CVD/lipid metabolism
APOC3 SstI cut site (G3238C) (30) (62) CVD/lipid metabolism
T-455C (69)
C-641A (70) (41)
APOE E4/e2 isoforms (2541) (53, 54, 58, 60, 71, 72) CVD, AD, stroke
CETP Ile405Val (73, 74) (41, 7577) CVD/lipid metabolism
FII G20210A (59) CVD
FGB G-455A (61, 78, 79) CVD
FVL Arg506Gln (61, 8083) CVD
Factor VII R353Q (25, 84, 85) (61, 78, 85) CVD
GPIa C807T (59) CVD
GPIIIa T1563C (59) CVD
MTHFR C677T (Ala222Val) (25, 83, 8690) (54, 59, 61, 91, 92) CVD, AD, osteoporosis
MTR D919G (93) (61) CVD
MTP G-493T and Q95H (94, 95) (41, 9698) CVD/lipid metabolism
PAI-1 4G/5G insertion (78, 79) (61, 99, 100) CVD
PON1 Gln192Arg (101-104) (41, 105) CVD/lipid metabolism
T-107C (105) (101)
Ht combinations, GWAS SNPs (102, 106, 107)
REN (108) CVD
TAFI G-438A (79) (61, 79) CVD
TP53 Arg72Pro (25, 109112) Cancer

Notes: Genes were included based on a Pubmed search with the following terms: gene | genetic & longevity | aging | age-related. Hits from this search were further investigated and additional references cited when appropriate. Final inclusion depended on relevance to particular disease processes versus aging mechanisms (Table 2). The search was first performed in fall 2006 and updated in March 2008. SNP = single nucleotide polymorphism; GWAS = genomewide association study.

*

This column shows disease or biological processes previously related to the gene cited to provide biological context.