Figure 3.

SBP (A), 24-h urine sodium excretion (U_NaV) (B), and 24-h urine volume (UV) (C) of mice (n = 10) lacking the subtype-2 (AT₂) angiotensin receptor (squares) and WT mice (n = 10; triangles) during vehicle infusion (day 0), during sustained s.c. infusion of ANG II (days 1–7, solid line) and during vehicle (V) infusion in the postexperimental control period (days 8–14). Baseline data for AT₂-null mice infused with vehicle (V) throughout the 14-day period were 104 ± 3 mmHg (SBP), 0.23 ± 0.04 milliequivalent/24 h (U_NaV), and 2.4 ± 0.6 ml/24 h (UV). There was no change from baseline for any of these parameters on any day of the 14-day vehicle infusion (P was not significant). ∗, P < 0.0001 from vehicle control (day 0); +, P < 0.0001 from WT mice.