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. Author manuscript; available in PMC: 2009 Jun 4.
Published in final edited form as: Immunity. 2007 Dec 27;28(1):122–133. doi: 10.1016/j.immuni.2007.11.017

Figure 2. Dose sensitivity of FTY720-mediated S1P1 modulation and induction of lymphopenia.

Figure 2

(A) FACS analysis of S1P1 on lymph node CD4+ T cells 4.5 h after in vivo treatment with the indicated amounts of FTY720. (B) Fraction of CD4+ T cells remaining in blood (BLD) and lymph (LYM) 4.5 h after treatment with the indicated amounts of FTY720 compared to saline treated controls. (C) FACS analysis of S1P1 on wild-type littermate control and Edg1+/- lymph node CD4+ T cells. (D) Number of CD4+ T cells in blood and lymph of wild-type and Edg1+/- mice. Data are representative of at least 3 mice for each condition. Bars represent means and dots individual mice.