Table 2.
Brain areas with regional white matter volume changes and MTR reductions (TS versus controls)
| Cluster size | Regions (Brodmann areas) | MNI-Space | t-value |
p-value (SVC) |
||
| x | y | z | ||||
| WMV: controls > TS | ||||||
| 157 | Right inferior frontal gyrus (9) | 44 | 3 | 25 | 4.35 | 0.010 |
| 81 | Left superior frontal gyrus (6) | -16 | 15 | 54 | 4.05 | 0.021 |
| 33 | Left precentral gyrus (6) | -25 | -20 | 70 | 3.93 | 0.027 |
| 115 | Right anterior corpus callosum | 7 | 34 | 10 | 3.92 | 0.028 |
| 79 | Left lingual gyrus (18) | -32 | -77 | -12 | 3.82 | - |
| WMV: TS > controls | ||||||
| 267 | Left postcentral gyrus (43) | -54 | -10 | 20 | 5.02 | 0.005 |
| 344 | Left precentral gyrus (6) | -26 | -12 | 53 | 4.00 | 0.023 |
| Left middle frontal gyrus (6) | -19 | -11 | 62 | 3.74 | 0.031 | |
| 42 | Left precentral gyrus (4) | -45 | -18 | 38 | 3.60 | 0.056 |
| 34 | Right parahippocampal gyrus (30) | 27 | -46 | 6 | 3.49 | 0.060 |
| 10 | Right precentral gyrus (44) | 49 | 10 | 11 | 3.39 | 0.085 |
| MTR maps: controls > TS | ||||||
| 99 | Right medial frontal gyrus (9) | 17 | 32 | 37 | 3,75 | 0.036 |
| 33 | Right inferior frontal gyrus (46) | 40 | 32 | 12 | 3,65 | 0.045 |
| 33 | Left inferior frontal gyrus (46) | -41 | 24 | 13 | 3,63 | 0.041 |
| 17 | Right cingulate gyrus (32) | 11 | 22 | 43 | 3,45 | 0.048 |
MNI = Montreal Neurological Institute, SVC = small volume correction, WMV = white matter volume, MTR = magnetization transfer ratio, TS = Tourette syndrome. No regions displayed significant regional increases in MTR maps for TS patients versus controls.