Table II.
Physiologic Parameter Values for the Sertraline Studies (Fasting Condition)
| Duodenal administration | Ileal–cecal junction administration | Ascending colon administration | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Compartment | Parameter values | Water volume (ml) | pH | Transit time (h) | Parameter values | Water volume (ml) | pH | Transit time (h) | Parameter values | Water volume (ml) | pH | Transit time (h) |
| Duodenum | 126a | 4a | 0.26 | – | – | – | – | – | – | ||||
| Jejunum1 | 44 | 4a | 0.93 | – | – | – | – | – | – | ||||
| Jejunum2 | 31 | 6.4 | 0.74 | – | – | – | – | – | – | ||||
| Ileum1 | 24 | 6.6 | 0.58 | – | – | – | – | – | – | ||||
| Ileum2 | 18 | 6.9 | 0.42 | – | – | – | – | – | – | ||||
| Ileum3 | 12 | 7.4 | 0.29 | 12 | 4a | 0.4a | 12 | 4a | 0.05a | ||||
| Small intestine water volume | 134b | – | – | – | – | – | – | – | – | ||||
| Ascending colon | 4.7 | 6.4 | 4.5 | 4.7 | 6.4 | 4.5 | 4.7 | 6.4 | 4.5 | ||||
| Distal colon | 5 | 6.8 | 13.5 | 5 | 6.8 | 13.5 | 5 | 6.8 | 4a | ||||
| Large intestine water volume | 9.7 | – | – | 9.7 | – | – | 9.7 | – | |||||
| T ppt (s) | 362 | – | – | 362 | – | – | 125 | – | – | ||||
| Fa (%) | 59 | – | – | 36 | – | – | 12 | – | – | ||||
All values of water volume, pH, and transit time are the default values, except where noted (GastroPlus percent fluid settings: 10% small intestine organ volume, 1% colon organ volume, 70 kg body weight)
aValues are not default values; values are adjusted to fit duodenal, ICJ, and AC intubation administrations
bRepresents the default value for total small intestine water volume when the GastroPlus percent fluid setting is 10% small intestine organ volume. Note, additional water introduced during the duodenal intubation resulted in the water volume value for duodenum to exceed the default value of 12 ml