Fig. 1.

The flux of nizatidine (0.1 mM) across Caco-2 cell monolayers in the absorptive (AP–BL) and secretory (BL–AP) directions and the corresponding P _app values, in the presence or absence of the P-gp inhibitor verapamil (0.1 mM). Data presented as mean ± SD; each experimental group represents studies across three transwells (n = 3); **p < 0.01