Table I.
The Concentration-Dependent Apparent Permeability (P app) of Nizatidine (0.1–10 mM) in the Absorptive (AP–BL) and Secretory (BL–AP) Directions and the Subsequent Efflux Ratio (P app BL–AP/P app AP–BL)
| Group | Donor concentration (mM) | AP–BL | BL–AP | ER |
|---|---|---|---|---|
| P app (×10−6 cm s−1) | ||||
| a | 0.1 | 0.27 ± 0.02 | 2.1 ± 0.2 | 7.7 ± 1.2 (f,g,h,i) |
| b | 0.25 | 0.35 ± 0.07 | 2.9 ± 0.2 | 8.2 ± 2.2 (f,g,h,i) |
| c | 0.5 | 0.36 ± 0.02 | 2.6 ± 0.2 | 7.2 ± 1.1 (f,g,h,i) |
| d | 0.75 | 0.43 ± 0.05 | 2.5 ± 0.3 | 5.8 ± 1.3 (g,h,i) |
| e | 1 | 0.43 ± 0.02 | 2.6 ± 0.2 | 6.0 ± 0.7 (g,h,i) |
| f | 2.5 | 0.52 ± 0.07 | 2.0 ± 0.3 | 3.9 ± 1.0 (a,b,c) |
| g | 5 | 0.66 ± 0.06 | 1.4 ± 0.1 | 2.1 ± 0.3 (a,b,c,d,e) |
| h | 7.5 | 0.82 ± 0.08 | 1.3 ± 0.2 | 1.6 ± 0.3 (a,b,c,d,e) |
| i | 10 | 1.11 ± 0.09 | 1.1 ± 0.1 | 1.0 ± 0.1 (a,b,c,d,e) |
Data presented as mean ± standard deviation; n = 3; letters represent significantly different groups
ER efflux ratio, BL–AP basolateral to apical, AP–BL apical to basolateral