Table II.

Observed and Predicted Metrics Describing the Plasma Concentration–Time Profile of Metoprolol After Administration in Three Formulations Covering a Range of Release Rates

Formulation	t max (h)		C max (mg/L)		AUC0–24 h (mg/L h)
	Observed	Predicted	Observed	Predicted	Observed	Predicted
Slow	4.86	3.97	0.06 (0.02)	0.06 (0.03)	0.7 (0.17)	0.77 (0.47)
Moderate	3.57	3.88	0.09 (0.03)	0.07 (0.03)	0.81 (0.03)	0.90 (0.56)
Fast	3.14	3.31	0.11 (0.03)	0.09 (0.04)	0.79 (0.02)	1.08 (0.58)

The observed data are from Sirisuth and Eddington (133).

The observed mean and SD values were only reported for C _max and AUC; t _max values were obtained from the graphs in (133).