Table IV.
Tissue distribution of transporters for which volume modulation has been investigated
| Transporter | Species | Tissue Expression | Reference |
|---|---|---|---|
| A. Efflux | |||
| P-gp | Human | adrenal, sweat glands, blood vessels, liver, kidney, lung > muscle, mammary glands, spleen, gall bladder, heart | (57) |
| P-gp (mdr1a/b) | Rat | brain > kidney > lung > liver | (3) |
| P-gp (mdr1a) | Mouse | adrenal > placenta> kidney, heart > liver, uterus, muscle, spleen, brain, lung | (58) |
| Mrp2 | Rat | liver > kidney, brain | (4) |
| Bcrp | Rat | kidney > liver > gonads > brain > thymus, spleen | (59) |
| Bcrp | Mouse | kidney > liver > gonads > brain > spleen, muscle, lung | (59) |
| B. OATPs | |||
| OATP1B1 | Human | liver | (54) |
| OATP2B1 | Human | liver, placenta, ciliary body | (54) |
| Oatp1a4 | Rat | liver, brain; eye | (45, 54) |
| C. OATs | |||
| OAT1 | Human | kidney > brain | (45) |
| OAT2 | Human | liver > kidney | (60) |
| OAT3 | Human | kidney > brain, | (45) |
| OAT4 | Human | kidney; placenta | (45, 61) |
| Oat1 | Rat | kidney > brain, | (45) |
| Oat2 | Rat | liver > kidney | (45) |
| Oat3 | Rat | liver ~ kidney, brain; eye | (45, 56, 61) |
| Oat4 | Rat | kidney, likely placenta | (62) |
| Oat1 | Mouse | kidney > brain | (45) |
| Oat2 | Mouse | kidney > liver (female > male) | (63) |
| Oat3 | Mouse | kidney > brain | (56) |
| Oat4 | Mouse | kidney, placenta | (62) |
| D. OCTs | |||
| OCT1 | Human | liver > kidney | (45) |
| OCT2 | Human | kidney > brain | (45) |
| OCT3 | Human | liver > kidney > brain | (45) |
| Oct1 | Rat | kidney, liver > brain | (45) |
| Oct2 | Rat | kidney | (45) |
| Oct3 | Rat | kidney, brain | (45) |