Table VII.

V_ss values from ex situ studies in rat

Interaction	Transporter	Organ	Vss Change	Prediction from Trends	Reference
Digoxin+Rifampin	Oatp1a4 uptake	Liver	↓ 17.9%	↓	(68)
Quinapril+PAH	Oat uptake	Kidney	↓ 13.7%*	↔, (↓)	(69)
Digoxin+Quinidine	P-gp efflux	Liver	↑ 95.9%	↓	(70)
Tacrolimus+GG918	P-gp efflux	Liver	↑ 30.1%	↓	(70)
Talinolol+GG918	P-gp efflux	Liver	↑ 74.2%	↓	(70)
Doxorubicin+GG918	P-gp efflux	Liver	↑ 70.2%*	↓	(71)

Italicized interactions are those where the data does not match the prediction from the present analysis.

* indicates calculated parameters, not reported in reference

PAH: p-aminohippurate, GG918: GF120918 (Elacridar)