Table III.

Key Biopharmaceutical and Pharmacokinetic Properties of Valacyclovir

Property	Value	Reference
S+Log P	−0.95	Estimated by ADMET Predictor (Simulations Plus, Inc.)
Aqueous solubility (mg/mL)	174	Merck index
Passive jejunal permeability (cm/s)	0.03 × 10−4	Estimated from Caco-2 Papp (37)
pK a values	Acid = 9.4	(45)
	Base1 = 1.9
	Base2 = 7.4
Clearance (L h−1 kg−1)	0.211	Fitted from 5 mg/kg i.v. infusion data
V c (L/kg)	0.216	Fitted from 5 mg/kg i.v. infusion data
K 12 (h−1)	1.31	Fitted from 5 mg/kg iv infusion data
K 21 (h−1)	0.87	Fitted from 5 mg/kg iv infusion data
First pass extraction (%)	34	Fixed across all five oral doses
Lumenal degradation (%/h) at pH = 5	2.69	(30)
Lumenal degradation (%/h) at pH = 6.5	40.4	(30)
Lumenal degradation (%/h) at pH = 7.5	80.6	(30)
In situ transporter K m (μM)	1200	(30)