Table 4.
Time-related changes by period analysis n (%)
| First period (Jan 1994-Jan 2000) | Second period (Feb 2000-Jan 2006) | P | |
| Patients (male:female) | 93 (63:30) | 143 (90:53) | NS |
| Age (yr) (mean, range) | 63.9 (40-81) | 62.5 (36-81) | NS |
| 1-yr survival rate | 88.3% | 85.6% | NS |
| 1-yr recurrence rate | 38.5% | 44% | NS |
| Anesthetic risk | |||
| ASA I-II | 60 (64.5) | 90 (62.9) | NS |
| ASA III-IV | 33 (35.5) | 53 (37.1) | NS |
| Number nodules | 1.77 (1-6) | 2.3 (1-11) | 0.012 |
| Size of nodules | 3.8 (0.8-11) | 3 (0.2-12) | NS |
| Bilobar disease | 19 (20.4) | 57 (39.9) | 0.002 |
| Extrahepatic disease | 1 (1.1) | 10 (7) | 0.03 |
| Preoperative CEA level (ng/dL) | 13.5 (0.4-3203) | 8.9 (0.6-1715) | 0.03 |
| Adjuvant treatment to CLM | 13 (14) | 49 (34.3) | 0.001 |
| Resectability rate | 69.9% | 86.7% | 0.002 |
| Use of intraoperative US | 91.3% | 92.9% | NS |
| Concordance of IOUS | 56.5% | 67.9% | NS |
| Procedures performed | 0.024 | ||
| Major hepatectomy | 23 (35.4) | 28 (22.6) | |
| Minor hepatectomy | 18 (27.7) | 48 (38.7) | |
| Atypical hepatectomy | 17 (26.2) | 20 (16.1) | |
| Combined hepatectomy | 7 (10.8) | 28 (22.6) | |
| Operative time (min) | 226.7 ± 58.8 | 251 ± 65.3 | 0.01 |
| Blood loss (mL) | 440 (25-1700) | 560 (80-2500) | NS |
| Need of transfusion | 40% | 44.7% | NS |
| Complications rate | 32.3% | 60.5% | 0.001 |
| Minor complications | 24.6% | 54% | 0.001 |
| Major complications | 7.7% | 5.6% | NS |
| Postoperative stay (d) | 11 (5-34) | 9 (4-43) | 0.018 |
| Postoperative mortality | 1.5% | 1.6% | NS |
| Complementary treatment of CLM | 60% | 49.2% | NS |