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Esophageal amelanotic malignant melanoma in Case 1. A: Low power view of the biopsy (HE, × 20); B: High power view of the biopsy. Malignant polygonal and spindle cells are seen. No melanin pigment is seen (HE, × 200); C: The tumor cells are positive for melanosome (HMB45). (Immunostaining, × 200); D: The tumor cells are positive for S100 protein (Immunostaining, × 200); E: The tumor cells are focally positive for KIT (Immunostaining, × 200).
