Table 1.

Effect of prolonged anaesthesia and progesterone administration on biodistribution of ¹¹C-SA4503

Tissue	Controla (n = 4)	Prolonged anaesthesiab (n = 5)	Progesterone-treated* (n = 4)	Effect of long anaesthesia (p)	Effect of progesterone (p)
Cerebellum	1.66 ± 0.18	2.41 ± 0.33	1.69 ± 0.30	< 0.01	NS
Cerebral cortex	1.50 ± 0.40	2.38 ± 0.40	1.85 ± 0.33	0.02	NS
Rest of brain	1.51 ± 0.38	2.12 ± 0.41	1.69 ± 0.37	NS	NS
Adipose tissue	0.25 ± 0.12	0.38 ± 0.15	0.25 ± 0.08	NS	NS
Bladder	0.67 ± 0.16	0.80 ± 0.31	0.55 ± 0.17	NS	NS
Bone	0.27 ± 0.08	0.42 ± 0.09	0.34 ± 0.11	< 0.05	NS
Bone marrow	1.56 ± 0.36	2.15 ± 0.23	1.17 ± 0.20	< 0.05	NS
Heart	0.35 ± 0.09	0.48 ± 0.07	0.31 ± 0.04	NS	NS
Large intestine	1.82 ± 0.36	2.62 ± 0.39	1.87 ± 0.39	< 0.05	NS
Small intestine	2.35 ± 0.28	3.48 ± 0.86	2.73 ± 0.53	NS	NS
Kidney	4.07 ± 0.45	4.60 ± 0.19	4.07 ± 0.63	NS	NS
Liver	7.53 ± 0.77	5.20 ± 0.28	7.16 ± 1.39	0.001	NS
Lung	2.21 ± 0.59	2.51 ± 0.62	1.92 ± 0.50	NS	NS
Muscle	0.18 ± 0.04	0.21 ± 0.01	0.20 ± 0.05	NS	NS
Pancreas	3.78 ± 1.55	5.06 ± 1.22	5.16 ± 1.60	NS	NS
Plasma	0.09 ± 0.03	0.10 ± 0.02	0.09 ± 0.01	NS	NS
Blood cells	0.05 ± 0.01	0.07 ± 0.01	0.05 ± 0.01	< 0.05	NS
Spleen	2.26 ± 0.39	3.76 ± 0.95	2.07 ± 0.41	< 0.05	NS
Submandibular gland	2.91 ± 0.91	2.08 ± 0.17	2.59 ± 0.85	NS	NS
C6 tumour	0.83 ± 0.11	1.52 ± 0.36	0.57 ± 0.14	< 0.05	< 0.05
Urine	0.48 ± 0.20	0.75 ± 0.76	0.92 ± 0.29	NS	< 0.05

SUV values of ¹¹C, 60 min after injection of ¹¹C-SA4503

^aData were obtained from the control and progesterone-treated rats, respectively, after the PET scan of Fig. 4

^bData were obtained from the rats which had undergone the two PET scans of Fig. 3