Table 6.

Analysis of frequency of transcription factor binding sites (TFBS) in WKY/SHR that are linked to consistently and consecutively differentially expressed genes and in SHR+ATCE/SHR that are linked to genes differentially expressed either up or down

	All ages in WKY/SHR			2 days and 2 weeks in WKY/SHR		SHR+ATCE/SHR shifted toward age-matched WKY/SHR
	z test			z test		z test
TF	2 days	2 weeks	48 weeks	2 days	2 weeks	2 days	2 weeks	48 weeks
CDP	↑	–	–	–	–	–	–	–
GATA-X	–	–	–	↑	↑↑	–	–	–
HFH-8	–	–	–	↑	–	–	–	–
XFD-2	–	–	–	↑↑	↑↑	–	–	–
ER	–	–	–	–	–	↑↑	–	–
GATA-3	–	–	–	–	–	↑	–	–
Gfi-1	–	–	–	–	–	↑	–	–
RFX1	–	–	–	–	–	↑	–	–
TGIF	–	–	–	–	–	↑	–	–
GR	–	–	–	–	–	–	↑↑	–
Oct-1	–	–	–	–	–	–	–	↑
XFD-1	–	–	–	–	–	–	–	↑↑

A size test was applied to determine the difference of frequency of a TFBS between the differentially expressed and non-differentially expressed genes (one or two arrows indicate P < 0.05 and P < 0.01, respectively). Increased frequency indicates that the binding site is more frequently activated or is stimulated

↑ increased frequency