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. Author manuscript; available in PMC: 2009 Jun 5.
Published in final edited form as: Front Biosci. 2008 Jan 1;13:1072–1082. doi: 10.2741/2745

Fig. 1. HDAC4 and HDRP -mediated neuroprotection.

Fig. 1

HDRP and HDAC4 mediate neuronal survival via distinct mechanisms. While HDRP binds to and inhibits the pro-apoptotic protein, JNK, therefore inhibiting c-Jun induction and phosphorylation, HDAC4 inhibits cell cycle progression by inhibiting CDK1 activity.